Abstract: Objective To investigate the value of US-CT /MRI fusion imaging in the precision radiofrequency (RF) therapy of primary liver cancer. Methods A total of 50 patients with primary liver cancer admitted from January 2014 to January 2019 were selected as the study subjects. According to whether the lesions were clearly displayed by conventional ultrasound, they were divided into the following two groups: 19 cases in the observation group with difficult ultrasound display, and 31 cases in the control group with clear ultrasound display. The observation group was guided by US-CT/MRI fusion imaging during RF ablation, while the control group was guided by conventional ultrasound during RF ablation. The completion of radiofrequency ablation, intraoperative supplementary ablation, postoperative complete ablation, postoperative complications, and 2-year survival rate were recorded in both groups. Results The completed RF ablation rates of the two groups were 94.74% and 100.00%, the intraoperative supplementary ablation rates of the two groups were 26.32% and 3.23%, and the postoperative complete ablation rates of the two groups were 100.00% and 93.55%, respectively. Compared with the control group, the observation group had a higher intraoperative supplementary ablation rate (P<0.05). There was no significant difference in completed RF ablation and postoperative complete ablation between the two groups (P>0.05). Within 2 years after treatment, 3 cases (15.79%) died in the observation group and 6 cases (19.35%) died in the control group. There was no significant difference in the 2-year survival rate between these two groups (P>0.05). The incidence of postoperative complications in these two groups was 0.00% and 3.23%, respectively. There was no significant difference in the incidence of postoperative complications between these two groups (P> 0.05). Conclusion US-CT/MRI fusion imaging has higher complete ablation rate and better safety in accurate radiofrequency ablation of primary liver cancer. For Lesions that are difficult to be detected by conventional ultrasound, US-CT/MRI fusion imaging can provide clear imaging thus has better clinical application value.

Key words: Primary liver cancer, Radiofrequency ablation, Ultrasonic examination, Computed tomography, Magnetic resonance imaging, Fusion imaging