Abstract: Objective To investigate the application value of multi-modal ultrasound imaging technology in screening high-risk population of liver cancer.Methods Two hundred patients with high risk of liver cancer admitted to our hospital from January 2020 to February 2021 were selected, and all of them underwent ultrasound elastography and contrast-enhanced ultrasound. Pathological results were used as the gold standard to analyze the diagnostic value of ultrasound elastography, contrast-enhanced ultrasound and the combination of the 2 in liver cancer.Results Thirty-six cases were diagnosed as liver cancer based on pathological results, and the incidence of liver cancer was 18.00%. The accuracy rates of ultrasound elastography and contrast-enhanced ultrasound in diagnosing liver cancer were both 86.00%, which were significantly lower than that of the combination of the 2 methods (94.00%) (χ²=7.111, P<0.05). The sensitivity of ultrasound elastography and contrast-enhanced ultrasound in diagnosing liver cancer were 63.89% and 69.44% respectively, which were significantly lower than that of the combination of the 2 methods (91.67%) (χ²=8.036, 5.675, P<0.05); the specificity of ultrasound elastography and contrast-enhanced ultrasound were 90.85% and 89.63 respectively, which were significantly lower than that of the combination method (96.34%) (χ²=4.121, 5.658, P<0.05); the positive predictive values of ultrasound elastography and contrast-enhanced ultrasound were 60.53% and 59.52%, which were significantly lower than than that of the combination method (84.62%) (χ²=5.631, 6.262, P<0.05); the negative predictive values of ultrasound elastography and contrast-enhanced ultrasound were 91.98% and 93.04%, which were significantly lower than than that of the combination method (98.14%) (χ²=6.511, 4.940, P<0.05).Conclusion The population with high risk of liver cancer is more likely to develop liver cancer. The multi-modal ultrasound imaging technology has a high diagnostic value in screening high-risk population of liver cancer, and can improve the accuracy, sensitivity and specificity of screening.

Key words: Multimodal ultrasound imaging technology, Ultrasound elastography, Contrast-enhanced ultrasound, High-risk population of liver cancer, Screening