Chinese Hepatolgy ›› 2022, Vol. 27 ›› Issue (3): 292-295.

• Liver Cancer • Previous Articles     Next Articles

Clinical value of imaging features and quantitative parameters of CEUS in differentiating hepatic inflammatory pseudotumor from intrahepatic cholangiocarcinoma

ZHU Ting1, LIN Li-ping2, WEI Yu-ya1   

  1. 1. Department of Ultrasound Medicine, Union Shenzhen Hospital, Huazhong University of Science and Technology,Guangdong 518052, China;
    2. Department of Ultrasound Medicine,the Eighth Affiliated Hospital of Sun Yat-sen University, Guangdong 518000,China
  • Received:2021-11-29 Online:2022-03-31 Published:2022-05-31

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Abstract: Objective To investigate the value of imaging characteristics and quantitative parameters of contrast-enhanced ultrasound (CEUS) in differentiating hepatic inflammatory pseudotumor (IPT) from intrahepatic cholangiocarcinoma (ICC).Methods Fifty-seven patients with ICC admitted to our hospital from April 2016 to July 2021 were selected into ICC group, and 32 patients with IPT were selected into IPT group. Most patients were confirmed by surgery or needle biopsy. All patients underwent CEUS examination at admission. Imaging features (dynamic enhancement mode, enhancement mode in arterial phase, enhancement degree in arterial phase) and quantitative parameters (arrival time of contrast agent, peak time, iso-enhancement time, start fading time) of CEUS were observed in 2 groups. Receiver operator characteristic (ROC) curve was used to analyze the value of peak time, iso-enhancement time and fading time in predicting ICC.Results The CEUS pattern of 35.09% patients in ICC group was swift enhancement and simultaneous expurgation, significantly lower than that in IPT group (68.75%), (P<0.05). The proportions of peripheral ring enhancement, heterogeneous enhancement and homogeneous enhancement in ICC group were 31.58%, 54.39% and 14.04%, respectively, and those in IPT group were 18.75%, 40.63% and 40.63%, respectively, the differences were statistically significant (P<0.05). The peak time, iso-enhancement time and fading time of ICC group were 26.56 ± 6.53, 33.53 ± 7.25, 48.12 ± 9.12s respectively, which were significantly higher than those of IPT group (22.93 ± 7.26, 27.53 ± 7.46, 41.75 ± 9.55s), and the differences were statistically significant (P<0.05). According to ROC analysis, the area under curve of peak time, iso-enhancement time and fading time in predicting ICC were 0.877, 0.925 and 0.924, respectively, with P<0.05.Conclusion Imaging features and quantitative parameters of CEUS have a certain value in differentiating ICC from IPT.

Key words: Contrast-enhanced ultrasound, Inflammatory pseudotumor of liver, Intrahepatic cholangiocarcinoma, Quantitative parameters