Abstract: Objective To summarize the clinical and laboratory findings of patients with end-stage primary biliary cirrhosis (PBC).Methods A retrospective summary and analysis of the laboratory examination results of 23 patients with end-stage PBC diagnosed in Beijing You'an Hospital affiliated to Capital Medical University, from January 2018 to December 2020.Results Among the 23 patients with end-stage PBC, the incidence of jaundice was 100%, and there were 18 cases (78.26%) with splenomegaly and thick spleen. The anemia was mainly mild to moderate anemia, and the hemoglobin of patients was 90-120 g/L, accounted for 43.39%, patients with hemoglobin of 60-90 g/L accounted for 47.83%. Patients with increased ALP accounted for 47.82%, and with increased γ-GT accounted for 8.70%. ALT (56.13±119.05) U/L, AST (92.04 ±124.46) U/L were considered to be a mild to moderate increase, and the degree of index rise and fall had no obvious correlation with the severity of the disease. Total cholesterol was (2.07±0.57) mmol/L, triglyceride was (0.99±0.54) mmol/L, and the degree of dyslipidemia of patients with end-stage PBC was significantly different from patients with early PBC.Conclusion Part of the laboratory indicators of patients with end-stage PBC are different from those of common PBC patients, the condition is more serious and the prognosis is worse.

Key words: End-stage liver disease, Primary biliary cirrhosis, Clinical analysis