Abstract: Objective To observe the levels of serum total bile acid (TBA), alkaline phosphatase (ALP) and coagulation function in patients with sepsis induced liver injury. Methods From March 2018 to March 2021, 85 sepsis patients with liver injury were selected as the observation group, and patients with sepsis without liver damage were selected as the control group during the same period. On the day of enrollment, the levels of serum TBA, ALP, D-dimer, activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen (FIB) were detected in the two groups. Results The levels of TBA and ALP in the observation group were (94.37±15.62) μmol/L and (24.59±4.33) μmol/L, respectively. The levels of TBA and ALP in the control group were (82.35±13.28) μmol/L and (19.85±3.62) μmol/L, respectively. And the levels of TBA and ALP in the observation group were higher than those in the control group (P<0.05). The levels of D-dimer, APTT, PT and FIB in the observation group were (3164.25±526.73) ng/mL, (35.28±7.14) s, (15.38±4.92) s, and (4.15±0.96) g/L in the control group, respectively. The levels of APTT, PT and FIB were (1624.37±328.17) ng/mL, (31.96±5.52) s, (13.84±5.02) s, (3.36±1.18) g/L, respectively. The levels of D-dimer, APTT, PT, FIB in the observation group were higher than those in the control group (P<0.05). Conclusion Sepsis can lead to liver function damage, increase of TBA and ALP levels, and abnormal coagulation function.

Key words: Sepsis, Liver injury, Total bile acid, Alkaline phosphatase, Coagulation function