Abstract: Objective To investigate the clinical value of magnetic resonance imaging (MRI) T2 weighted imaging (T2WI) and multiphase 64 slice spiral computed tomography (64-MDCT) in the differential diagnosis between nodules and small hepatocellular carcinoma (HCC) in patients with liver cirrhosis.Methods Seventy-six cirrhotic patients with nodular or small HCC admitted to our hospital from March 2018 to March 2021 were enrolled. All the subjects underwent MRI T2WI scan and multiphase 64-MDCT scan before operation. Taking the Results of postoperative histopathology as the gold standard, the diagnostic value the 2 Methods was evaluated by consistency analysis.Results The Results of postoperative pathological examination showed that there were 46 patients with small HCC and 30 patients with cirrhotic nodules.The Results of MRI T2WI showed that there were 43 patients with small HCC and 33 patients with cirrhotic nodules (including 13 cases of liver cirrhosis with degenerative nodules and 20 cases of liver cirrhosis with regenerative nodules).The Results of multiphase 64-MDCT showed that there were 39 patients with small HCC and 37 patients with cirrhotic nodules. The consistency analysis showed that the sensitivity and specificity of MRI T2WI in the diagnosis of small HCC were 0.891 and 0.933, respectively. The sensitivity and specificity of multiphase 64-MDCT were 0.804 and 0.933, respectively. The sensitivity and specificity of combined diagnosis were 0.935 and 0.967, respectively.Conclusion MRI T2WI and multiphase 64-MDCT can be used in the differential diagnosis of nodules and small HCC in patients with liver cirrhosis, and the combined examination has higher sensitivity and specificity.

Key words: Magnetic resonance imaging, T2 weighted imaging, Cirrhosis, Small hepatocellular carcinoma, Computed tomography