Abstract: Objective To analyze the clinical characteristics and prognostic factors of HBV-related chronic acute liver failure patients with lung infection.Methods A total of 75 HBV-related chronic acute liver failure (HBV-ACLF) patients who were admitted to our hospital from March 2018 to January 2019 were selected and divided into the lung infection group (lung infection, LI) according to whether they had pulmonary infection. ) 37 cases in the group and 38 cases in the no lung infection (NLI) group. Collect and analyze the complications of the two groups of patients, check the six biochemical indicators of cholesterol, serum sodium, alpha-fetoprotein, albumin, PTA, and C-reactive protein in the two groups, use the Child-Pugh score to assess the prognosis of the patients, and analyze the two The correlation between biochemical indicators and prognosis of patients in the group.Results Compared with the NLI group, the incidence of coagulation dysfunction, upper gastrointestinal hemorrhage, hepatic encephalopathy, and hepatorenal syndrome in the LI group increased significantly, and the difference was statistically significant (P<0.05), while the incidence of ascites was higher There is no statistical difference. Serum biochemical index Results showed that compared with patients without lung infection, the expression levels of serum cholesterol, serum sodium, alpha-fetoprotein, albumin, and PTA in patients with lung infection decreased, while CRP and PCT were significantly increased. The difference was statistically significant (P<0.05). The Child-Pugh score Results showed that the average Child-Pugh score of the non-pulmonary infection group was 5.3±0.43 points, and the score of the combined lung infection group was 8.6±3.3 points. There was a significant difference between the two (P<0.01). The Results of Spearman correlation analysis showed that Child-Pugh score was positively correlated with CRP and PCT content, and the correlation was statistically significant (P<0.0001). Child-Pugh scores are negatively correlated with cholesterol, serum sodium, alpha-fetoprotein, albumin and PTA, and the correlations are statistically significant (cholesterol P<0.05, serum sodium, alpha-fetoprotein, albumin and PTAP<0.0001).Conclusion Pulmonary infection in patients with chronic acute liver failure can aggravate the symptoms and affect the prognosis of the patients. The expression of cholesterol, serum sodium, serum albumin, C-reactive protein, PTA, alpha-fetoprotein and PCT may affect the combination of HBV-ACLF An important factor for the prognosis of patients with lung infection.

Key words: acute-on-chronic liver failure, lung infection, Child-Pugh, correlation analysis