Abstract: Objective To analyze the clinical characteristics of patients with drug-induced liver injury (DILI).Methods The clinical data of 170 DILI patients admitted to Taizhou People's Hospital from July 2015 to July 2020 were retrospectively analyzed. Multivariate logistic regression, Kruskal-Wallis H test and ROC-AUC were used to analyze the data.Results The age of 170 patients was (46.69±13.53) years old, of which 125 were female (73.5%). The top three suspicious drugs: 102 cases (60.0%) of Chinese herbal medicines (Polygonum multiflorum, Tripterygium wilfordii, Sedum tatarinowii, Panax notoginseng, Houttuynia cordata, Dandelion, Black bone vine, Leprosy grass, etc.) and dietary supplements (weight loss meal replacement agents, enzymes, vitamin complexes, weight loss agent), 28 cases (16.5%) of antibacterial drugs, and 14 cases (8.2%) of non-steroidal anti-inflammatory drugs. There were 118 cases (69.41%) of hepatocellular type, 29 cases (17.06%) of cholestatic type, and 23 cases (13.53%) of mixed injury type. A total of 18 patients underwent liver biopsy, and pathology basically were consistent with DILI diagnosis, but the consistency between the clinical types and pathological types was not ideal (K value=0.04<0.4). Age≥40 years old (P=0.025; OR=2.731; 95%CI: 1.134, 6.576), drinking (P=0.003; OR=5.348; 95%CI: 1.786, 16.234) and diabetes (P=0.01; OR=8.848; 95%CI: 1.699, 46.073) are independent risk factors for DILI. Two patients who took Sedum tatarinowii capsules for more than 1 month died.Conclusion DILI patients are mostly 41-60 years old and women. Chinese herbal medicine and dietary supplements are the main pathogenic factors of DILI. Hepatocellular type is the main clinical type of DILI. Liver biopsy is helpful for diagnosis, but it is not a necessary diagnostic method for DILI. Most patients have a good prognosis.

Key words: Drug-induced liver injury, Clinical features, Clinical types, Chinese herbal