Chinese Hepatolgy ›› 2022, Vol. 27 ›› Issue (7): 742-747.

• Liver Failure • Previous Articles     Next Articles

Effects of obesity on the severity and mortality in patients with HBV-ACLF and decompensated cirrhosis: A retrospective cohort study

MO Rui-dong1, ZHANG Zheng-lan2, YIN Rong-kun3, ZHOU Yan-mei4, WANG Yue5, YIN Peng-bo6, ZHANG Chen-xi1, FU Hao-shuang1, QIAN Cong1, XIANG Xiao-gang1, XIE Qing1   

  1. 1. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
    2. Department of Infectious Diseases, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China;
    3. Department of Infectious Diseases, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200050, China;
    4. Department of Infectious Diseases, the people's Hospital of Xingan, Guangxi Zhuang Autonomous region 541399, China;
    5. Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University, Jiangsu 215006, China;
    6. Department of Infectious Diseases, Luohe Central Hospital, Henan 462005, China
  • Received:2022-06-08 Online:2022-07-31 Published:2022-08-25
  • Contact: ZHANG Zheng-lan, Email:zzljxygan@sina.com

PDF (PC)

190

Abstract: Objective To investigate the effects of obesity on short-term mortality in patients with hepatitis B virus-related acute on chronic liver failure (HBV-ACLF) and decompensated cirrhosis.Methods Ninty-three patients with HBV-ACLF and 285 patients with decompensated cirrhosis admitted to our hospital were enrolled. Baseline clinical data and risk factors of metabolism were collected. The 90-day and 180-day mortality of patients was recorded. Survival analysis was performed by log-rank test and Kaplan-Meier method. Multivariate analysis of survival was performed by Cox-regression proportional hazards model.Results Among all the patients, there were 146 (38.6%) cases with obesity, which was the major metabolic comorbidities. In I group (25≤BMI<30), the incidence rate of infection in patients with obesity was significantly than that in patients without obesity (44.1% vs 30.6%, χ2=6.37, P=0.042). The proportion of obesity in non-survival group was significantly higher than that in survival group (55.8% vs 36.4%, χ2=6.05, P=0.014). Multivariate analysis showed that obesity was positively correlated with 180-day mortality (HR 2.07, 95% CI 1.13-3.78, P=0.018). The 90-day mortality and 180-day mortality of obesity group were significantly higher than those of non obesity group (χ2=6.17, P=0.013; χ2=5.16, P=0.023).Conclusion Obesity is a risk factor which positively correlated with short-term mortality in patients with HBV-ACLF or decompensated cirrhosis. Close monitoring and early interventions in this part patients are necessary.

Key words: Acute on chronic live failure, Hepatitis B, Liver cirrhosis, Metabolic syndrome, Obesity