Chinese Hepatolgy ›› 2022, Vol. 27 ›› Issue (7): 756-758.

• Viral Hepatitis • Previous Articles     Next Articles

HBsAg clearance rate and its influence factors in preschool children with HBeAg negative chronic hepatitis B treated with antiviral therapy

ZHANG Feng-xiao1, ZHANG Jia-wei1, BAI Xue-song1, HU Chun-xia1, ZENG Yan-li2   

  1. 1. Department of Infection, Zhoukou Central Hospital, Henan 466000, China;
    2. Department of Infectious Diseases, Henan Province People’s Hospital, Henan Provincial Key Laboratory of Hepatology, Zhengzhou People’s Hospital of Zhengzhou University, Henan 450003, China
  • Received:2021-06-30 Online:2022-07-31 Published:2022-08-25

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Abstract: Objective To investigate the clearance rate of hepatitis B surface antigen (HBsAg) in preschool children with hepatitis B e antigen (HBeAg) negative chronic hepatitis B (CHB) treated with antiviral therapy and to analyze the influence factors.Methods Sixty-eight patients with HBeAg negative CHB treated in our hospital were enrolled. All the children received antiviral therapy. The clinical data of HBsAg clearance rate was collected. The general data including serum alanine transaminase (ALT) level, hepatitis B virus (HBV) DNA level, HBsAg level (at baseline and after treatment) were collected. Influencing factors of HBsAg clearance rate were analyzed.Results Twenty children (29.41%) with HBsAg clearance were selected into clearance group and 48 cases (70.59%) without HBsAg clearance were selected into non-clearance group. The average age[(2.86 ± 0.62) years], baseline HBV DNA level [(9.89±2.54) × 106 U/mL] and baseline HBsAg level [(2.62 ± 0.50) lgIU/mL] of the clearance group were significantly lower than those of the non clearance group[(4.84 ± 0.54) years, (11.23 ± 2.10) × 106U/mL, (2.98 ± 0.42) lgIU/ml (P<0.05)], and the decrease level of HBsAg at the 24th week of treatment [(1.60 ± 0.41) lgIU/ml] was significantly higher than that of the non clearance group[(0.84 ± 0.28) lgIU/ml (P<0.05)]. Multivariate logistic regression analysis showed that age (OR=1.520, 95%CI=1.140~2.027), baseline HBV DNA level (OR=1.480,95%CI=1.140 ~ 1.921), baseline HBsAg level (OR=1.654, 95%CI=1.370 ~ 1.997), decreased level of HBsAg at the 24th week of treatment (OR=1.286, 95%CI=1.021 ~ 1.620) were independent influencing factors of HBsAg clearance rate in preschool children with HBeAg negative CHB (P<0.05).Conclusion HBsAg clearance may occur in some preschool children with HBeAg negative CHB after antiviral therapy. Age, baseline HBV DNA level, baseline HBsAg level and the decrease level of HBsAg at the 24th week of treatment are the independent influencing factors of HBsAg clearance rate.

Key words: Hepatitis B, Antiviral, Preschool children, Hepatitis B e antigen, Hepatitis B surface antigen, Clearance rate