Analysis on the correlation between IL-17 family cytokines and intestinal flora in patients with chronic hepatitis B

Abstract

Abstract: Objective To investigate the correlation between interleukin-17 (IL-17) family cytokines and intestinal microflora in patients with chronic hepatitis B (CHB).Methods Seventy-four CHB patients admitted to our hospital from January 2018 to January 2020 were selected as the observation group, and 80 healthy subjects were selected as the control group during the same period. The levels of IL-17 family cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F) in serum of the 2 groups were detected 1 day after enrollment. The levels of 9 kinds of intestinal flora in the 2 groups were detected. The correlation between IL-17 family cytokines and intestinal flora levels in CHB patients was analyzed.Results The contents of Enterobacteriaceae, Enterococcus faecalis, Clostridium, Bacteroidetes, Prevotella and Bifidobacterium in the observation group [(7.51±0.87), (8.89±1.16), (9.28±1.08), (11.36±1.92), (9.48±1.62), (6.89±0.91) lg Copies/g] significantly higher than those in the control group [(7.06±0.82), (7.38±0.92), (7.32±0.78), (10.12±1.55), (7.82±1.25), (5.09±0.72) lg copies/g], P<0.05. The levels of IL-17 family cytokines in the observation group [(231.65±33.14), (279.36±41.05), (242.36±32.65), (245.73±35.61), (265.49±34.96), (217.58±26.73) pg/mL] were significantly higher than those in the control group [(58.16±5.62), (68.82±12.15), (65.37±4.02), (67.12±6.23), (62.18±6.25), (50.47±3.51) pg/mL], (P<0.05). The levels of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F were all positively correlated with the levels of Enterobacteriaceae, Enterococcus faecalis, Clostridium, Bacteroidetes, Preverobacteria and Bifidobacteria (P<0.05).Conclusion The IL-17 family cytokines levels are positively correlated with the levels of Enterobacteriaceae, Enterococcus faecalis, Clostridium, Bacteroidetes, Preverobacterium and Bifidobacterium. And there is no significant difference between the levels of IL-17 family cytokines and Lactobacillus, Ruminococcus, Candidella albicans.

Key words: Hepatitis B virus, Chronic hepatitis B, Interleukin-17, Cytokines, Intestinal flora

ZHANG Yi, WANG Zhou, YANG Bin. Analysis on the correlation between IL-17 family cytokines and intestinal flora in patients with chronic hepatitis B[J]. Chinese Hepatolgy, 2022, 27(7): 759-761.

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