The guiding value of intravoxel incoherent motion diffusion-weighted imaging in the curative effect of argon-helium knife cryotherapy on primary liver cancer

Abstract

Abstract: Objective To explore the guiding role of Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in the curative effect of argon-helium cryotherapy for patients with primary liver cancer (PLC).Methods A total of 112 patients with PLC admitted to the hospital from February 2016 to July 2019 were selected as the research objects. The patients were all treated with cryotherapy with argon helium knife. The patients were examined by IVIM-DWI at 1 day prior and 1 month after the operation. They were followed up for 1 year and divided into recurrence group and non-recurrence group according to whether their PLC recurred after operation. The clinical data and IVIM-DWI parameters before and after surgery in these two groups were collected and compared. Logistic regression analysis was used to explore the factors affecting the recurrence of PLC. The receiver operating characteristic curve (ROC) was used to determine the predictive value of IVIM-DWI parameters for postoperative recurrence of patients with PLC.Results After a 1-year’s follow-up, 112 patients with PLC received cryotherapy with argon-helium knife. There were 16 (14.29%) cases in the recurrence group and 96 cases in the non-recurrence group. The tumor size of the recurrence group was higher than that of the non-recurrence group (P<0.05). The standard postoperative diffusion coefficient (ADC) and postoperative pure diffusion coefficient (D) of the recurrence group were lower than those of the non-recurrence group (P<0.05). The proportion of cases with TNM staging of stage II in the recurrence group was higher than that in the non-recurrence group (P<0.05). Logistic multivariate regression analysis showed that postoperative ADC value, postoperative D value, and tumor size were all influencing factors for the recurrence of PLC (P<0.05). The ROC analysis showed that the postoperative D and ADC values have a certain diagnostic power in predicting the recurrence of PLC after surgery (P<0.05).Conclusion The D and ADC values of IVIM-DWI parameters of PLC patients at one month post cryotherapy with argon-helium knife cryotherapy have certain efficacies in predicting the recurrence of PLC.

Key words: Argon-helium knife freezing, Primary liver cancer, Diffusion-weighted imaging of incoherent motion within voxel, Influencing factors, Predictive value

MA Jun-wei, LIU Ji-qiang, SONG Ran. The guiding value of intravoxel incoherent motion diffusion-weighted imaging in the curative effect of argon-helium knife cryotherapy on primary liver cancer[J]. Chinese Hepatolgy, 2022, 27(7): 778-781.

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