Chinese Hepatolgy ›› 2022, Vol. 27 ›› Issue (8): 853-857.

• Frontier, Exploration and Controversy • Previous Articles     Next Articles

Differential expression and prognostic value of serum miRNA in patients with hepatitis B virus-related acute-on-chronic liver failure

XIE Zhi-wei, LU Ai-qi, YANG Ke-li, CHEN Bin-bin, GUAN Yu-juan, XIAO Guang-ming, LI Jian-ping   

  1. Department of Liver Diseases Division,Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangdong 510060, China
  • Received:2021-11-13 Online:2022-08-31 Published:2022-09-30
  • Contact: LI Jian-ping, Email: 13570303667@126.com

Abstract: Objective To investigate the prognostic value of serum miRNA in hepatitis B virus-related chronic and acute liver failure (HBV-ACLF), and to guide clinical diagnosis and treatment.Methods Patients with hepatitis B virus infection admitted to our hospital from May 2018 to May 2019 were enrolled. All the patients were divided into HBV-ACLF group and chronic hepatitis B (CHB) group, a health control (HC) group was also established. The differential expression of miRNA among the 3 groups were analyzed.Results A total of 75 patients (59 males and 16 females) were included, with an average age of 39.7±9.1 years. There were 30 patients in HBV-ACLF group (17 cases were improved and 13 cases were not cured), 20 cases in CHB group and 25 cases in HC group. There was no significant difference in sex, age, creatinine level and white blood cell count among the 3 groups (P>0.05). Compared with cases in CHB group and HC group, patients in HBV-ACLF group had lower erythrocyte count, hemoglobin level and platelet count (P<0.001), higher levels of alanine aminotransferase, aspartate aminotransferase (P<0.001). The expression levels of miRNA-144-3P, miRNA-205-5p, miRNA-96-5p and miRNA451a were significantly up-regulated in HBV-ACLF group (P<0.05). In HBV-ACLF group, the expression levels of miRNA-205-5p and miRNA-96-5p in patients with condition improved were up-regulated, the difference was statistically significant (P<0.05).Conclusion The miRNA expression profiles in patients with HBV-ACLF is significantly different from that in CHB patients and healthy people. High expression of miRNA 205-5p and miRNA 96-5p in patients with HBV-ACLF may indicate a good prognosis.

Key words: Hepatitis B virus, Acute-on-chronic liver failure, MicroRNA, Prognosis