Abstract: Objective To investigate the etiology and clinical characteristics of patients with liver cirrhosis with first hospitalization in recent 5 years. And to prevent, diagnose and treat liver cirrhosis based on etiology, as well as improve the survival rates.Methods The clinical data of patients with liver cirrhosis admitted to our hospital from January 2016 to December 2020 were retrospectively analyzed. The distribution of causes was recorded. The clinical data of plasma D-dimer levels in different liver functional status of cirrhosis, ascites, and spontaneous bacterial peritonitis (SBP) were collected. And the clinical significances were analyzed.Results Among the 986 patients with liver cirrhosis, 431 complicated with hepatitis B virus (HBV) infection, 146 complicated with alcoholic liver disease and 124 complicated with cryptogenic liver disease. There were significant differences in plasma D-dimer levels among different Child-pugh classification, (Child-pugh score C > B >A, P<0.05). The median of plasma D-dimer in ascites group and non-ascites group were 2.16 mg/L and 0.49 mg/L, respectively (P<0.05); The median of D-dimer in ascites SBP groupand non-ascites group were 4.52 mg/L and 1.98mg/L, respectively (P<0.05).Conclusion The main cause of liver cirrhosis is still HBV infection. The D-dimer level of patients with liver cirrhosis is closely related to the severity of liver function injury. If the level of D-dimer is significantly increased, ascites and SBP should be paid more attention to.

Key words: Liver cirrhosis, Etiology, D-dimer