Abstract: Objective To investigate the clinical value of GPR parameter model combined with FibroScan for evaluating the stage of liver fibrosis in patients with chronic hepatitis B (CHB).Methods A total of 161 patients with CHB who underwent liver biopsy in our hospital were selected. The clinical date liver stiffness measurement (LSM), gamma-glutamyl transpeptidase (GGT), platelet (PLT) and GPR at 1 week before puncture were collected. To analyze the correlation between GPR, LSM and the degree of liver fibrosis; to analyze the accuracy of GPR parameter model combined with FibroScan in the diagnosis of liver fibrosis in CHB patients.Results The liver LSM values of CHB patients with degree of fibrosis from F0 to F4 were 5.06±1.48, 5.65±1.48, 6.29±1.14, 8.65±2.75 and 14.03±4.24KPa, respectively; and the differences were statistically significant (F=64.327, P<0.001). The LSM value was positively correlated with the stage of pathology (r=0.730, P<0.001). The GPR values of CHB patients with degree of fibrosis from F0 to F4 were 0.32±0.22, 0.46±0.40, 0.57±0.50, 0.80±0.72 and 1.20±1.06, respectively; and the differences were statistically significant (F=4.921, P<0.001). The GPR value was also positively correlated with pathological staging (r=0.384, P<0.05). The area under the curve (AUC) values of LSM, GPR, and LSM combined with GPR for the diagnosis of F≥2 were 0.851, 0.711, and 0.862, respectively. The AUC values of LSM, GPR, and LSM combined with GPR for the diagnosis of F≥3 were 0.899, 0.722 and 0.911, respectively. The AUC values of LSM, GPR, and LSM combined with GPR for the diagnosis of F=4 were 0.921, 0.711 and 0.926, respectively.Conclusion The predictive value of LSM combined with GPR in the diagnosis for liver fibrosis is better than that of LSM or GPR alone. GPR parameter model combined with Fibroscan can be used as a more accurate non-invasive diagnosis model for liver fibrosis, which is worthy of clinical application.

Key words: Hepatitis B, Liver fibrosis, Transient elastograph, Parameter model