Abstract: Objective To observe the isolated bacterial strains and drug sensitivity in patients with hepatitis B-related cirrhosis comorbided with pulmonary infection.Methods The clinical data of 123 cases of patients with hepatitis B-related cirrhosis complicated with pulmonary infection were retrospectively analyzed. Sputum samples were collected from all patients. The distribution of isolated bacterial strains and drug sensitivity were analyzed.Results Of the pathogenic bacteria, there were 60.40% of gram negative bacteria, 38.26% of gram positive bacteria, and 1.34% of fungi. Gram-negative bacteria were the main pathogens. The main isolated strains of gram-negative bacteria and gram-positive bacteria were resistant to a variety of antibiotics, the sensitivity rates of Klebsiella pneumoniae to ertapenem, imipenem and amikacin were more than 70%. The sensitivity rates of Escherichia coli to ceftazidime, aztreonam, ertapenem, imipenem and amikacin were more than 70%. The sensitivity rates of Staphylococcus aureus to vancomycin, ciprofloxacin and Levofloxacin etc. were more than 70%. The sensitivity rates of coagulase negative Staphylococcus to vancomycin were more than 70%. Klebsiella pneumoniae and Escherichia coli strains have certain positive rates of extended-spectrum β-lactamase (ESBL) (>30%) and carbapenemase (<30%).Conclusion The strains isolated from patients with hepatitis B related cirrhosis and pulmonary infection are mainly gram-negative bacteria. Gram-negative and gram-positive isolates are resistant to a variety of antibiotics. Klebsiella pneumoniae and Escherichia coli strains are positive for ESBL.

Key words: Hepatitis B, Cirrhosis, Pulmonary infection, Isolated strains, Drug sensitivity