Abstract: Objective To investigate the correlation between inducible Decoy Receptor 3 (DCR3), the C-reactive protein to albumin ratio (CRP/Alb), and thioredoxin (Trx) in patients with pyogenic liver abscess, especially in those with concurrent infectious shock. Methods From January 2019 to December 2021,,100 patients with pyogenic liver abscess admitted to the hospital were prospectively selected for our study, and the expression levels of DCR3, CRP/Alb, and Trx in all patients were assessed. Based on the presenece or absence of infectous shock within 1 week of admission, patients were categorized into either the ‘occurrence group’ or the ‘non-occurrence group’. The clinical data and laboratory indices between these two groups were compared. Finally, the correlation between DCR3, CRP/Alb, Trx and the incidence of infectious shock in these patients was analyzed. Results Out of 100 patients with pyogenic liver abscess, 21(21%) experienced infectious shock.. The levels of DCR3, CRP, CRP/Alb, and Trx were notably higher in the occurred group compared to the non-occurred group (t=3.626、6.115、4.182、3.572,P<0.05); Logistic regression analysis indicated that DCR3, CRP/Alb and Trx could be potential risk factors for infectious shock complications in patients with pyogenic liver abscess (OR=3.425、2.794、1.137, P<0.05). Through point biserial correlation analysis, DCR3, CRP/Alb, and Trx demonstrated a positive correlation with infectious shock arsing from pyogenic liver abscess(r=0.342、0.391、0.340, P<0.05). Furthermore, the ROC curve showed that DCR3, CRP / Alb, and Trx had predicted AUC values of 0.713,0.740, and 0.719 for septic shock, indicating their potential as predictive value. Conclusion DCR3, CRP/Alb, and Trx are strongly associated with the onset of infectious shock in patients with pyogenic liver abscess. They can be utiilized to predict and assess the likelihood of infectious shock in such patients.

Key words: Pyogenic liver abscess, Infectious shock, Decoy Receptor3, C-reactive protein/albumin, Thioredoxin