Abstract: Objective To explore the application value of “Liver Hemodynamics Software” in diagnosing liver fibrosis stages.Methods The spectrum waveforms of portal vein, left hepatic vein, middle hepatic vein and right hepatic vein were detected by color Doppler ultrasound, and the heart rates were measured by M-mode ultrasound. The spectrum images and heart rates were uploaded to the “Liver Hemodynamics Software” system produced by Hangzhou Jingkang Technology. The liver fibrosis values were then calculated, and further compared with the pathological diagnosis of Percutaneous Liver Biopsies.Results Among 148 patients, 32 cases were diagnosed as stage 0, 39 cases as stage 1, 24 cases as stage 2, 12 cases as stage 3 and 41 cases as stage 4. According to the diagnostic values of Liver Hemodynamics Software, 148 patients were divided into four groups, and the area under the receiver operating characteristic curve (AUC) of each group was AUC=0.91 (95% confidence interval 0.867~0.959), 0.962 (95% confidence interval 0.938~0.987), 0.975 (95% confidence interval 0.956~0.994), and 0.966 (95% confidence interval 0.940~0.993), respectively. According to the principle of maximum Jordan index, the cutoff values of staging liver fibrosis for ≥ S1, S2, S3 and S4 by liver hemodynamics software were 1.27, 3.78, 3.98 and 5.85, respectively. The Liver Hemodynamics Software showed a high accuracy in assessing whether there had severe fibrosis and cirrhosis. The AUC of each phase was greater than 0.9, of which S3>S4>S2>S1.Conclusion As a new non-invasive method for detecting liver fibrosis, the liver fibrosis values obtained by Liver Hemodynamics Software has a good correlation with the pathological stagings of liver fibrosis, thus may accurately evaluate the degrees of liver fibrosis, and can be widely used in clinical practice.

Key words: Hepatic hemodynamics, Color Doppler ultrasound, Portal vein, Hepatic vein, liver fibrosis Stages