Chinese Hepatolgy ›› 2023, Vol. 28 ›› Issue (11): 1346-1350.

• Non-alcoholic Fatty Liver Disease • Previous Articles     Next Articles

Analysis of liver function and associated metabolic factors in heterogeneous fatty liver disease

SHI A-meng1, WANG Ying1, MA Wen-qi1, LIU Na1, ZHOU Zhi-hua2, ZHOU Qi1, SHI Hai-tao3, DONG Lei3   

  1. 1. Medical Ultrasound Laboratory, the Second Affiliated Hospital of Xi′an Jiaotong University, Shaanxi 710004,China;
    2. Department of Health Management the Second Affiliated Hospital of Xi′an Jiaotong University, Shaanxi 710004,China ;
    3. Department of Gastroenterology, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an, Shaanxi 710004,China
  • Received:2023-04-28 Online:2023-11-30 Published:2024-03-03
  • Contact: DONG Lei, Email: dong7256@163.com

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Abstract: Objective To investigate liver function and associated metabolic related factors in heterogeneous fatty liver disease.Methods In a cohort of 180 individuals each from groups with heterogeneous fatty liver, homogeneous fatty liver, and healthy cohorts matched for gender and age, the body mass index (BMI), liver function, blood pressure, blood glucose, lipid profiles and uric acid levels were compared.Results (1) Of the 180 cases diagnosed with heterogeneous fatty liver, 167 were identified as type Ⅲ (diffuse heterogeneous infiltrative). In these, a pronounced, finely enhanced punctate echogenicity was observed in the majority of the liver tissue, contrasted by hypoechogenicity in certain areas. This hypoechogenicity was ambiguously demarcated from the normal liver parenchyma, with no evident space-occupying effect. (2)In the 180 cases of heterogeneous fatty liver, the majority comprised men (75.6%), those under 45 years of age (52.8%), and individuals with a BMI ≥ 28 kg/m2 (43.3%). Furthermore, 74.4% of these cases presented with normal ALT, 25.6% exhibited elevated ALT, and 6.1% display an ALT increase exceeding twice the normal range. (3) When compared to the healthy population, the levels of ALT, AST, ALP and GGT were fournd to be elevated in both heterogeneous fatty liver and homogeneous fatty liver, However, the levels of ALT, AST and GGT were notably lower in the heterogeneous fatty liver group than in the homogeneous fatty liver group. (4) Compared to the healthy population, indices such as BMI, blood pressure, blood glucose, blood cholesterol, triglycerides and uric acid levels were elevated in both heterogeneous and homogeneous fatty liver groups. Yet, the BMI, blood glucose and triglyceride measurements were found to be lower in the heterogeneous fatty liver compared to the homogeneous fatty liver group. (5) The BMI, blood glucose, blood triglycerides and uric acid were identified as independent influencing factors for heterogeneous fatty liver. Their respective OR (95% CI) values were 1.634 (1.362, 1.959), 1.878 (1.244, 2.835), 2.844 (1.049, 7.710), and 1.029 (1.019, 1.039).Conclusion Heterogeneous fatty liver primarily presented as diffuse heterogeneous infiltration, with BMI, blood glucose, blood triglycerides, and uric acid identified as independent risk factors.

Key words: heterogeneous Fatty Liver, BMI, Blood Glucose, Blood Triglycerides, Blood Uric Acid