Abstract: Objective To explore the diagnostic value of Fibro-Touch and “Liver Hemodynamics Software” (PMD) for the degree of liver fibrosis in chronic hepatitis B patients.Methods Eighty-two chronic hepatitis B patients and 32 normal individuals were selected as the study cohorts. Liver stiffness (LSM) was measured with FibroTouch in all subjects. Simultaneously, color Doppler ultrasound was used to detect the spectrum waveform of blood flow in portal vein, left hepatic vein, middle hepatic vein, and right hepatic vein. M-mode ultrasound was used to measure heart rate. The obtained blood flow spectrum images and heart rate were uploaded to the “Liver Hemodynamics Detection Software” system to calculate the liver blood flow frequency value (LBFF). The liver hardness value measured by FibroTouch and the frequency of liver blood flow measured by PMD were compared with the pathological diagnosis of liver tissue puncture biopsy.Results For the pathological diagnosis of liver tissue of 82 patients with chronic hepatitis B, 33 cases were in stage 1, 22 cases were in stage 2, 10 cases were in stage 3, and 17 cases were in stage 4. The liver hardness values of 114 subjects ranged from 3.7 to 55.1kPa, showing a significant positive correlation with liver fibrosis stages (r=0.811, P<0.01); The frequency of liver blood flow ranged from 0 to 26Hz, which was positively correlated with the stages of liver fibrosis (r=0.831, P<0.01). The cutoff values of LSM≥S1, ≥S2, ≥S3, and=S4 were 6.05, 7.95, 11.2, and 10.35 kPa, respectively, and the AUC were 95.9%, 88.3%, 91.6%, and 90%, respectively; The sensitivities were 89%, 93.9%, 88.9%, and 100%, respectively; The specificities were 100%, 78.5%, 83.9%, and 73.2%, respectively. The cutoff values for LBFF ≥S1, ≥S2, ≥S3, and=S4 were 1.233, 1.99, 3.8, and 5.815 Hz, respectively; The AUC values were 0.899, 0.939, 0.944, and 0.972, respectively. The sensitivities were 78%, 78.8%, 88.9%, and 88.2%, respectively; The specificity were 100%, 83.1%, 83.9%, and 95.9%, respectively.Conclusion FibroTouch and PMD, as non-invasive methods for detecting liver fibrosis, have a good correlation with the pathological stages of liver fibrosis. They can accurately evaluate the degrees of liver fibrosis and can be widely used in clinical practice.

Key words: FibroTouch, Liver hemodynamic software, Color Doppler ultrasound, Portal vein, Hepatic vein, Staging of liver fibrosis