Changes of intestinal flora after radical resection of primary liver cancer combined with TACE

Abstract

Abstract: Objective To analyze the changes in intestinal flora in patients with primary liver cancer following radical resection combined with transcatheter arterial chemoembolization (TACE).Methods A total of 114 patients with primary liver cancer treated in our hospital from January 2020 to January 2023 were included in the study. The control group (57 cases) underwent radical liver cancer surgery, while the observation group (57 cases) received combined TACE treatment after radical liver cancer surgery. The clinical efficacy of the two groups was compared, and serum indices as well as the number of lactobacillus, enterobacter, yeast, bifidobacterium and other bacteria were measured. The correlation between these factors was analyzed by the Pearson correlation coefficient.Results The disease control rates in the observation group and the control group were 94.74% and 80.70%, respectively. The observation group had a significantly higher disease control rate compared to the control group (P<0.05). After treatment, the serum levels of alpha-fetoprotein (AFP), tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6) in the observation group were (581.64±47.32) ng/mL, (85.13±15.37) pg/mL, and (124.39±15.73) pg/mL, respectively, which were significantly lower than those of control group [(662.37±52.49) ng/mL, (92.53±19.84) pg/mL, (145.81±19.77) pg/mL, respectively]. The levels of interleukin-2 (IL-2) were (86.22±5.84) pg/mL, which was significantly higher than that in control group [(80.26±7.33) pg/mL, P<0.05]. After treatment, the number of lactobacilli and bifidobacteria in the observation group were (10.52±1.77) lgCFU/g and (10.84±2.25) lgCFU/g, respectively, which were significantly higher than those in the control group [(8.34±1.63) lgCFU/g and (9.52±1.37) lgCFU/g, respectively]. The number of Enterobacteriaceae and yeast in the observation group were (9.93±2.71) lgCFU/g and (5.91±1.37) lgCFU/g, respectively, which were significantly lower than those in the control group [(13.95±3.82) lgCFU/g and (7.83±1.58) lgCFU/g, P＜0.05]. Correlations were observed between serum AFP expression and the number of Lactobacillus, Enterobacter, yeast and bifidobacterium (r=-0.522, 0.498, 0.503, -0.518, P=0.034, 0.041, 0.039, 0.034). Furthermore, the expression of TNFα in serum was correlated with the numbe of intestinal flora (r=-0.637, 0.622, 0.574, -0.592, P=0.005, 0.005, 0.021, 0.018). The expression of serum IL-2 was also correlated with the number of intestinal flora (r=0.536, -0.508, -0.529, 0.564, P=0.032, 0.039, 0.034, 0.023). Similarly, the expression of serum IL-6 was correlated with the number of intestinal flora (r=-0.613, 0.572, 0.603, -0.517, P=0.006, 0.021, 0.007, 0.034).Conclusion TACE treatment following radical surgery for primary liver cancer can improve the disease control rate, promote intestinal microbiota balance, and reduce inflammatory factor levels.

Key words: Primary liver cancer, Radical resection of liver cancer, Transcatheter arterial chemoembolization, Intestinal microbiota

REN Hong-tao, WANG Yu-ting, YIN Jia-feng, SU Wang-hui. Changes of intestinal flora after radical resection of primary liver cancer combined with TACE[J]. Chinese Hepatolgy, 2023, 28(12): 1450-1454.

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