Changes and clinical significance of serum uric acid level in type 2 diabetes patients with nonalcoholic fatty liver disease

Abstract

Abstract: Objective To observe the variations in serum uric acid levels among patients with type 2 diabetes mellitus(T2DM) and nonalcoholic fatty liver disease(NAFLD) and assess its clinical implications.Methods Between December 2020 and December 2022, 118 patients with T2DM admitted to our hospital were selected, including 64 males and 54 females, aged (57.78±4.07) years. Based on the presence or absence of NAFLD complications, patients were divided into combined group (n=88) and non-combined group (n=30). A retrospective study was carried out. Variables showing statistical differences were subjected to multivariate Logistic regression analysi.Results The BMI for the combined group was (26.72±2.53) kg/m², while it was (23.31±2.17) kg/m² for the non-combined group. The difference was statistically significant (P<0.05). The fasting blood glucose and HOMA-IR levels in the combined group were (8.82±1.45) mmol/L and (3.58±0.95), respectively, which were significantly higher than those in the non-combined group [(7.67±1.23) mmol/L and (3.05±0.79), P<0.05]. The levels of ALT, AST, total cholesterol, triglyceride and LDL in the combined group were (37.94±2.68) U/L, (29.20±2.61) U/L, (5.38±1.13) mmol/L, (2.46±0.64) mmol/L and (3.31±0.80) mmol/L, respectively. In comparison, the non-combined group had values of (23.27±2.16) U/L, (21.71±2.03) U/L, (4.34±1.02) mmol/L, (1.32±0.55) mmol/L and (2.56±0.62) mmol/L. The difference between the groups was statistically significant (P<0.05). The serum uric acid in the combined group was (349.14±28.45) μmol/L, compared to (273.34±17.29) μmol/L in the non-combined group, and the difference was statistically significant (P<0.05) . Additionaly, the LDL level in the combined group was (1.35±0.38) mmol/L, which was significantly lower than the (2.29±0.43) mmol/L observed in the non-combined group(P<0.05). According to the multivariate Logistic regression analysis, when incorporating the above differences into the study, it was suggested that BMI, HOMA-IR and serum uric acid were risk factors for T2DM complicated with NAFLD (OR values were 4.604, 5.150 and 4.978, respectively, P<0.05).Conclusion Patients with T2DM may also present with complications related to NAFLD. BMI, HOMA-IR and serum uric acid are the main risk factors that warreant greater attention in clinical settings.

Key words: Type 2 diabetes, Nonalcoholic fatty liver disease, Blood uric acid

XIONG Qi-jun, ZHU Wen. Changes and clinical significance of serum uric acid level in type 2 diabetes patients with nonalcoholic fatty liver disease[J]. Chinese Hepatolgy, 2023, 28(12): 1476-1479.

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