The efficacy and safety of carrilizumab combined with ramvaritinib in the treatment of unresectable hepatocellular carcinoma

Abstract

Abstract: Objective To investigate the efficacy and safety of carrelizumab combined with ramvaritinib in the treatment of unresectable hepatocellular carcinoma (HCC). Methods Twenty-six unresectable HCC patients were divided into a control group and an observation group. The control group was treated with ramvaritinib, and the observation group was treated with carrelizumab. The changes of tumor markers, clinical efficacy, follow-up time, survival indexes and major adverse drug reactions were observed. Results After 1 and 3 months of treatment, the levels of serum alpha-fetoprotein (AFP) and abnormal prothrombin (PIVKA-II) in both groups were decreased compared with those before treatment, and the decrease range in observation group was higher than that in control group (P<0.05). The Objective response rate (ORR), local control rate (DCR) and conversion rate in the observation group were significantly higher than those in the control group, and the median response time (mRT) was shorter and the median duration of response (mDR) was longer than that in the control group (P<0.05). The median follow-up time (mFUP), median overall survival (mOS), median progression-free survival (mPFS) and the extent of long diameter reduction of target lesions in the observation group were significantly higher than those in the control group, and the mortality was lower than that in the control group (P<0.05). There was no grade 5 adverse reactions between the two groups, and there was no significant difference in the incidence of grade 3-4 reactions between the two groups (P>0.05). Conclusion The combination of Caririzumab with ramvaritinib may improve the clinical efficacy of ramvartinib on unresectable HCC patients, prolong the patients' survival with high safety.

Key words: Hepatocellular carcinoma, Unresectable, Carrellizumab, Ramvaratinib, Conversion rate, Survival Time

QIAN Hou-long, LI Yang, ZHU Xiang, LU Kui. The efficacy and safety of carrilizumab combined with ramvaritinib in the treatment of unresectable hepatocellular carcinoma[J]. Chinese Hepatolgy, 2023, 28(4): 452-456.

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