Abstract: Objective To investigate the risk factors associated with the occurrence of adverse pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP).Methods Three hundred and sixty-five pregnant women with ICP who delivered at Shunde Women and Children's Hospital of Guangdong Medical Universityt, Foshan, Guangdong Province, from June 2019 to December 2021 were selected. Pregnant women with ICP were grouped according to whether they had adverse pregnancy outcomes, and the differences in clinical characteristics between the two groups were observed.Results Univariate analysis showed that time of ICP onset, age, total bile acid, direct bilirubin, glutamic oxalacetic transaminase, glutamic alanine transaminase, twin pregnancy, and embryo transfer were associated with adverse pregnancy outcome ( t/χ²=29.369、2.342、4.006、2.111、2.622、2.089、27.801、11.795,P＜0.05); maternal type, BMI, and gestational diabetes were not associated with adverse pregnancy outcome (t/χ²=0.193、0.517、1.321,P>0.05). logistic regression analysis showed that age(31.04±5.13year),total Bile acid (37.17±30.70μmol/L), femur length(64.88±6.52 mm),twin pregnancy, glutathione (34.51±46.37 U/L)and uric acid(369.69±117.78 μmol/L) were independent risk factors for adverse pregnancy outcome in pregnant women with ICP (P<0.05).Conclusion Age, total bile acids, femur length, twin pregnancy, glutathione and uric acid are high risk factors for adverse pregnancy outcomes in pregnant women with ICP.

Key words: Intrahepatic cholestasis of pregnancy, Adverse pregnancy outcomes, Risk factors, Total bile acid