Abstract: Objective To study the clinical effect of 125 iodine particle strips combined with biliary stents in the treatment of malignant obstructive jaundice.Methods 56 patients with malignant obstructive jaundice from May 2017 to October 2021 were selected and divided into control group (15 cases) and study group (41 cases).In the two groups,the overall survival time, liver function, complications, clinical efficacy and stent patency time were compared.Results Direct bilirubin (DBIL),alanine aminotransferase (ALT),aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels of 4 weeks after surgery were lower than before surgery (P<0.05), but there were no differences in ALT, TBIL, DBIL and AST 4 weeks after surgery between the two groups (P>0.05). The clinical success rates of the study group and the control group were 95.12% and 93.33%, respectively, with no difference (P>0.05). The total complication rates of the control group and the study group were 13.33% and 14.63%, respectively, with no difference (P>0.05). The median stent patency time of the study group and the control group were 241 d and 147 d, respectively, and the study group with function of stent patency time was better than control group (P<0.05). The median survival time of the control group and the research group was 165 d and 253 d, respectively, and the study group with total survival function was better than control group (P<0.05).Conclusion Biliary stent implantation combined with biliary cavity radiotherapy with 125 iodine particle strips can prolong the overall survival time and stent patency time of patients with malignant obstructive jaundice, which is effective, improves liver function, and is safe and reliable.

Key words: Biliary stent implantation, 125 iodine particle bar, Intravascular radiation of biliary tract, Malignant obstructive jaundice, Clinical curative effect