Diagnostic value of echocardiography combined with plasma NT proBNP in patients with alcohol dependent cirrhosis with cardiac insufficiency

Abstract

Abstract: Objective To investigate the diagnostic value of echocardiography combined with plasma N-terminal pro B-type natriuretic peptide (NT proBNP) in patients with alcohol dependent-cirrhosis with cardiac insufficiency (CIS). Methods From May 2020 to May 2022, 79 patients with alcohol dependent-cirrhosis in the Ultrasound Department of Fuyang Third People's Hospital were enrolled. They were divided into CIS group and non-CIS group. All patients received echocardiography and the plasma NT proBNP level test. The clinical data, Tei index and plasma NT proBNP level between the two groups were compared to analyze the influencing factors of CIS. The diagnostic value of Tei index combined with plasma NT proBNP level for CIS were further evaluated. Results In CIS group, the duration of cirrhosis was (3.12 ± 0.40) years, the proportion of cirrhosis grade C was 58.82%, AST was (79.23 ± 8.92) U/L, ALT was (68.52 ± 9.21) U/L. It was higher than those in non-CIS group, with duration of cirrhosis as (2.44 ± 0.35) years, the proportion of 16.13%, ALT of (58.25 ± 6.23) U/L, AST of (51.28 ± 7.10) U/L (P<0.05). Tei index (0.59 ± 0.16) and plasma NT proBNP level (251.36 ± 39.47) pg/mL in CIS group were also higher than those in non-CIS group (0.48 ± 0.11) and (178.25 ± 30.19) pg/ml (P<0.05). Logistic regression analysis showed that the course of liver cirrhosis, liver cirrhosis grade, Tei index, and plasma NT proBNP level were the risk factors for CIS (P<0.05). The Receiver operating characteristic curve (ROC) analysis showed that the cut-off values of patients with alcohol dependent cirrhosis diagnosed by Tei index and plasma NT proBNP level were 0.54 and 227.42U/ml, AUC values were 0.873 and 0.750. And the AUC value predicted by Tei index combined with plasma NT proBNP level is 0.932. Conclusion Echocardiography combined with plasma NT proBNP showed a high diagnostic value for CIS in patients with alcohol dependent cirrhosis.

Key words: Echocardiography, N-terminal B-type natriuretic peptide, Alcohol dependent cirrhosis, Cardiac insufficiency

XUE Xue, GAO Qin, ZHAO Sheng. Diagnostic value of echocardiography combined with plasma NT proBNP in patients with alcohol dependent cirrhosis with cardiac insufficiency[J]. Chinese Hepatolgy, 2023, 28(7): 767-771.

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