Abstract: Objective To study on the relationship between Helicobacter pylori (Hp) infection and non-alcoholic liver disease (NAFLD), and to observe the changes of metabolic parameters before and after Hp eradication. Methods A total of 490 patients who underwent physical examination in Qinhuangdao Military Hospital were divided into a NAFLD group (N=127 cases) and a control group (N=363 cases). The general data and serological indicators of these two groups were compared. The influencing factors of NAFLD were analyzed by Logistic regression, and the metabolisms of glucose and lipid were observed before and after the eradication treatment of Hp. Results The body mass index was (25.36±2.97)kg/m² in the NAFLD group, and (21.53±2.62)kg/m² in the control group (t=13.685, P<0.001). There were 30 cases (23.62%) of hypertension in the NAFLD group and 24 cases (6.61%) of hypertension in the control group (χ²=27.763, P<0.001). The alanine aminotransferase level was (31.03±22.56)U/L in the NAFLD group and (17.15±12.25) U/L in the control group (t=8.641, P<0.001). The glutamic oxaloacetic transaminase level was (23.24±11.67)U/L in the NAFLD group and (17.97±7.52)U/L in the control group (t=5.821, P<0.001). The level of LDL cholesterol was (2.84±0.84) mmol/L in the NAFLD group and (2.52±0.68) mmol/L in the control group (t=4.283, P<0.001). The level of high density lipoprotein cholesterol was (1.20±0.27)mmol/L in the NAFLD group and (1.61±0.39)mmol/L in the control group (t=10.960, P<0.001). The total cholesterol level was (5.11±1.02)mmol/L in the NAFLD group and (4.69±0.93)mmol/L in the control group (t=4.270, P<0.001). Triacylglycerol level was (2.38±1.81)mmol/L in the NAFLD group and (1.30±0.95)mmol/L in the control group (t=8.510, P<0.001). The fasting blood glucose was (4.98±1.28)mmol/L in the NAFLD group, and (4.49±0.96)mmol/L in the control group (t=4.518, P<0.001). There were 54 cases (42.52%) of Hp infection in the NAFLD group and 112 cases (30.85%) in the control group (χ²=5.716, P=0.017). Logistic regression analysis showed that body mass index (OR=4.125, 95%CI: 1.792~9.495), hypertension (OR=3.793, 95%CI: 1.836~7.836), alanine aminotransferase (OR=3.412, 95%CI: 1.625~7.164), aspartate aminotransferase (OR=3.314, 95%CI: 1.568~7.004), low-density lipoprotein cholesterol (OR=2.506, 95%CI: 1.307~4.805), high-density lipoprotein cholesterol (OR=2.741, 95%CI: 1.110~6.769), total cholesterol (OR=3.644, 95%CI: 1.194~11.121), triglyceride (OR=2.815, 95%CI: 1.246~6.360), fasting blood glucose (OR=3.488, 95%CI: 1.712~7.106) and Hp infection (OR=3.073, 95%CI: 1.429~6.608) were the influencing factors of NAFLD (P<0.05). The fasting blood glucose, fasting insulin, insulin resistance index, total cholesterol, triglyceride and low density lipoprotein cholesterol of NAFLD patients with Hp infection after Hp eradication treatment were (6.17±0.69)mmol/L, (7.66±1.34)μIU/mL, (2.11±0.31) and (3.25±0.68), (1.54±0.42)mmol/L, (0.94±0.30)mmol/L, respectively, which were lower than those of (6.91±1.04)mmol/L, (11.18±2.83)μIU/mL, (3.62±0.50), (6.62±1.51) mmol/L, (4.53±1.33) mmol/L, (3.63±0.73) mmol/L before treatment, On the contrary, the level of high density lipoprotein cholesterol was (2.75±0.62)mmol/L, which was higher than that of (1.39±0.54)mmol/L before treatment (P<0.05). Conclusion Hp infection is correlated with NAFLD. It is necessary to actively eradicate Hp for the treatment of NAFLD.

Key words: Helicobacter pylori, Nonalcoholic liver disease, Correlation, Metabolic markers