Chinese Hepatolgy ›› 2024, Vol. 29 ›› Issue (1): 37-40.

• Drug-Induced Liver Injury • Previous Articles     Next Articles

An analysis on the clinical biochemical and pathological characteristics of simple cholestatic type of drug induced liver injury

BAI Huan-huan1, FENG Hui-jun2, GUO Li-jie3, ZHANG Hai-cong3, HE Xiao-yan3, MENG Shuang3, ZHANG Xiang-e1   

  1. 1. The Fifth Hospital of Shijiazhuang, Hebei 050021, China;
    2. Hebei Chest Hospital, Shijiazhuang 050000, China;
    3. The Second Hospital of Shijiazhuang, Hebei 050056, China
  • Received:2023-04-28 Online:2024-01-31 Published:2024-03-01
  • Contact: ZHANG Xiang-e,Email:346912846@qq.com

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Abstract: Objective To analyze the clinical, serum biochemistry and histopathological characteristics of patients with simple cholestatic type of drug induced liver injury (DILI). Methods Thirty-eight patients were diagnosed as simple cholestatic type of DILI with Liver biopsy. The causative drugs, disease course, R value for DILI classification, peak value and changing trend of liver biochemical indexes and histopathology were collected. The correlation between different pathological characteristics and the disease course and liver biochemical indexes were analyzed. Results Simple cholestatic type of DILI was more common in male patients <40 years old, but more common in female patients >40 years old. The most common drugs causing simple cholestatic type of DILI were Chinese herbs (36.8%), the next were antibiotics (13.2%) and antipyretic analgesic drugs (13.2%). Most R values are <2 (mean=1.5). The peak and recovery time of liver biochemical indexes have different characteristics. There was a moderate correlation between the score of canalicular cholestasis and TBil value (r=0.545, P=0.016). The scores of small bile duct degeneration was moderately correlated with the peak value of γ-glutamyl transpeptidase (GGT) (r=0.538, P=0.021).There was no correlation between other pathologic scores and the peak value of liver biochemical indexes (P>0.05).The course of disease was positively correlated with cholestasis in canalicular and hepatocyte (r=0.528, P=0.024; r=0.500, P=0.041). Peak time of TBil was positively correlated with canalicular cholestasis (r=0.672, P=0.002). The normal time of GGT was positively correlated with the degeneration of small bile duct (r=0.551, P=0.018). There was no correlation between other pathologic scores and the peak and recovery time of liver biochemical indexes (P>0.05). Conclusion Simple cholestatic type of DILI has its unique clinical, pathological and hepatic biochemical characteristics and disease evolution course.

Key words: Simple cholestasis, Drug induced liver injury, Clinical features, Characteristics of liver biochemistry, pathological features