Abstract: Objective To explore the efficacy of plasma exchange (PE) combined with dual plasma molecular adsorption system (DPMAS) in the treatment of patients with drug-induced liver failure. Methods A retrospective analysis was conducted on 64 patients with drug-induced liver failure (grade 3 to 4 of drug-induced liver injury) admitted to the department of infectious diseases of Yueyang Central Hospital from June 2020 to February 2021. Among them, 32 were in the PE combined with DPMAS treatment group and 32 were in the drug treatment alone group. Results The clinical efficacy of the two groups post-treatment, the alterations in liver function and coagulation function indicators pre-and post-treatment, as well as the incidence of clinical adverse reactions were compared. The combined use of PE and DPMAS group yielded a significantly higher total effective rate (87.5%) than that of the drug alone group (65.6%). PE combined with DPMAS group had more advantages in reducing bilirubin and improving blood coagulation function (P=0.017 and 0.025, respectively),and there was no statistical difference between the two groups in reducing glutamic pyruvic transaminase and glutamic oxalic transaminase (P=0.497 and 0.103, respectively). Conclusion The incidence of adverse reactions was not significantly different between the two groups.The utilization of both plasma exchange and dual plasma molecular adsorption system is a safe and effective treatment for individuals suffering from drug-induced liver failure.

Key words: Liver failure, Artificial liver, Plasma exchange, Dual plasma molecular adsorption system, Drug-induced liver injury