Abstract: Objective To investigate the clinicopathological characteristics of hepatic angiosarcoma and analyze its diagnostic difficulties. Methods The pathological and clinical data of 6 patients diagnosed with hepatic angiosarcoma in the department of pathology of Beijing Hospital from 2013 to 2022 were retrospectively analyzed. Results The clinical manifestations and images of the 6 patients with hepatic angiosarcoma were non-specific. The morphologies were diverse. Atrophic liver cell plates and hepatic sinusoids lined with atypia cells were observed in high-grade angiosarcoma, while low-differentiated angiosarcoma was more atypical, and should be distinguished from other sarcomas. The tumor cells expressed vascular endothelial markers CD31, CD34 and ERG. Conclusion Hepatic angiosarcoma is a rare malignant tumor without specificity in clinical manifestations and image examinations. Comprehensive analyses of the clinical manifestations, morphology and immunohistochemical staining are helpful for a right pathological diagnosis.

Key words: angiosarcoma, liver, pathology