Abstract: Objective To investigate the influence factors of ultrasound-guided microwave ablation on the long-term treatment outcomes of recurrent liver cancer. Methods We collected data from 80 patients with recurrent liver cancer treated at our hospital from September 2019 to September 2021 and conducted a retrospective analysis. The patients were divided into a poor prognosis group (22 deaths) and a good prognosis group (55 survivals) based on their 1-year postoperative survival. Clinical data were compared between the two groups, including serum levels of alpha-fetoprotein (AFP), albumin (Alb), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Multiple Logistic regression analysis was conducted to identify the factors influencing the long-term efficacy of ultrasound-guided microwave ablation in patients with recurrent liver cancer. Results In the poor prognosis group, 8 cases (36.36%) of patients were classified as Child-Pugh grade B, 11 cases (50.00%) had multiple lesions, 10 cases (45.45%) had lesion diameter ≥3 cm, and 9 cases (40.91%) had AFP ≥100 ng/mL. In comparison, the good prognosis group had 8 cases (13.79%) with Child-Pugh grade B, 12 cases (20.69%) with multiple lesions, 13 cases (22.41%) with lesion diameter ≥3 cm, and 10 cases (17.24%) with AFP ≥100 ng/mL. These differences were found to be statistically significant (P＜0.05). Multivariate Logistic regression analysis further confirmed that Child-Pugh grade B, multiple lesions, lesion diameter ≥3 cm, and AFP≥100 ng/mL were identified as risk factors for a poor prognosis in patients with recurrent liver cancer after ultrasus-guided microwave ablation (P<0.05). Conclusion Ultrasound-guided microwave ablation has better long-term efficacy for patients with Child-Pugh grade A, single lesion, lesion diameter < 3 cm, and AFP < 100 ng/mL.

Key words: Ultrasonic guided microwave ablation, Recurrent liver cancer, Curative effect, Influencing factor