Abstract: Objective To explore the clinical characteristics of hepatitis B-related cirrhosis complicated by spontaneous enterococcus peritonitis (SEP), and analyze the influencing factors of the complication. Methods From July 2018 to March 2023, 120 patients were admitted with hepatitis B related cirrhosis. Among them, 55 patients complicated with SEP were classified as concurrent group, and the remaining 65 patients were classified as non-concurrent group. The clinical characteristics of patients in these two groups were compared, and the risk factors of SEP in hepatitis B-related cirrhosis were analyzed. Results The proportion of gastrointestinal bleeding, previous treatment with antibiotics, and history of abdominal surgery in the concurrent group was 32.7%, 85.5%, and 43.6%, respectively, which were higher than those in the non-concurrent group (12.3%, 49.2%, and 7.7%); The levels of albumin and creatinine were (29.5 ± 3.6) g/L and (95.7 ± 9.4) respectively μmol/L, lower than the non-concurrent group [(32.9 ± 4.3) g/L, (121.7 ± 11.8) μmol/L, P<0.05]. By multivariate logistic regression analysis it was found that gastrointestinal bleeding, previous antimicrobial treatment, history of abdominal surgery, low albumin and low creatinine were all risk factors for SEP in hepatitis B-related cirrhosis patients (OR=4.721, 4.623, 5.013, 5.286, 5.124, P<0.05). Conclusion The risk of SEP in hepatitis B-related cirrhosis is high,with gastrointestinal bleeding, history of antimicrobial treatment, abdominal surgery, and low levels of albumin and creatinine as the risk factors, which warrant clinical attention.

Key words: Hepatitis B-related cirrhosis, Spontaneous enterococcus peritonitis, Clinical characteristics, Influencing factors