Efficacy of microecological agents combined with ornithine aspartate in treatment of patients with subclinical hepatic encephalopathy and its influence on liver function and cognitive function

Abstract

Abstract: Objective To observe the therapeutic effect of microecological agents combined with ornithine aspartate in treatment of patients with subclinical hepatic encephalopathy (SHE) and its influence on liver function and cognitive function. Methods A total of 86 SHE patients were collected from January 2020 to December 2023, and were randomly divided into two groups. The control group (43 cases) received ornithine aspartate treatment, and the observation group (43 cases) received ornithine aspartate combined with microecological agents. Before treatment and 8 weeks after treatment, the blood ammonia, C-reactive protein (CRP), procalcitonin (PCT), and liver function indicators [aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ- Glutamyltransferase (γ- GT) and total bilirubin (TBil)] were measured. The cognitive function was evaluated by the Number Connection Test (NCT-A), NCT-B, and Digital Sign Test (DST). Results Compared to control group after treatment, the blood ammonia (66.69±18.19 μmol/L vs. 87.88±21.35 μmol/L), CRP (6.57±1.43 mg/L vs. 9.56±1.71 mg/L), PCT ( 0.21±0.08 ng/L vs. 0.29±0.09 ng/L), AST(49.14±9.75 U/L vs. 55.21±11.06 U/L), ALT(35.81±5.79 U/L vs. 48.35±7.21 U/L), γ- GT (60.89±9.71 U/L vs. 73.25±11.61 U/L) and TBil (45.61±7.32 U/L vs. 50.37±8.42 U/L) both decreased in the observation group, with statistical significance (all P<0.05). Compared to control group after treatment, the levels of NCT-A (56.68±11.06 vs. 60.01±12.14), NCT-B (67.76±12.83 vs. 71.85±14.69), and DST (105.42±21.68 vs. 126.48±23.41) in the observation group were significantly higher (all P<0.05). There was 4.65% of patients converted to HE in the observation group, significantly lower than the HE conversion rate of 16.28% in control group (P<0.05). Conclusion The combination treatment of microecological agents and ornithine aspartate can reduce blood ammonia and inflammatory factor levels, protect liver and cognitive function in SHE patients, and may reduce the risk of HE conversion.

Key words: Subclinical hepatic encephalopathy, Microecological preparations, Aspartate ornithine, Liver function, Cognitive function

LI Yan, CHEN Qian, ZHOU Shu-ping, LIU Xin-kuang, XU Bin. Efficacy of microecological agents combined with ornithine aspartate in treatment of patients with subclinical hepatic encephalopathy and its influence on liver function and cognitive function[J]. Chinese Hepatolgy, 2024, 29(7): 821-824.

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