Abstract: Objective This study aims to summarize the clinical characteristics of eosinophilic gastroenteritis (EGE) to enhance awareness, diagnosis, and management of the disease. Methods We retrospectively collected clinical data from 27 EGE patients diagnosed between January 2016 and March 2023 at Beijing Friendship Hospital, Capital Medical University. Subgroup analyses were performed based on ascites, classification, liver function, spontaneous remission, and prognosis. Results The onset age of the 27 EGE patients was 35.00 years, with a higher prevalence in males (Male: Female ratio, 2.3:1). The stomach and/or duodenum were most commonly affected (70.37%), with the mucosal type being the predominant classification (59.26%). A majority of patients (85.19%) showed elevated peripheral eosinophil (EOS) counts. In subgroup analyses, patients with the serosal type had significantly higher peripheral EOS counts and rates of eosinophilic ascites compared to those with mucosal and muscular types (12.85 vs 8.24 vs 11.11×10⁹/L, P=0.029; 87.50% vs 6.25% vs 0, P<0.001). Patients treated with corticosteroids showed significantly higher peripheral EOS counts, EOS%, and Immunoglobulin E (IgE) levels compared to those with spontaneous remission (2.77 vs 0.56×10⁹/L, P=0.016; 29.30% vs 8.05%, P=0.045; 200.00 vs 20.39 IU/mL, P<0.001). The combination of peripheral EOS count and IgE level demonstrated good predictive power for spontaneous remission (AUC 0.92, 95% CI 0.82-1.00). Conclusion EGE is a rare gastrointestinal inflammatory disease that often involves the stomach and duodenum. Corticosteroid therapy is recommended for patients with elevated peripheral EOS counts and IgE levels.

Key words: Eosinophilic Gastroenteritis, Corticosteroids, Treatment, Spontaneous Remission