Effectiveness of ultrasound-guided percutaneous transhepatic cholangiographic drainage for treating malignant obstructive jaundice and its influence on serum inflammatory markers

Abstract

Abstract: Objective To evaluate the effectiveness of ultrasound-guided percutaneous transhepatic cholangiographic drainage (PTCD) in patients with malignant obstructive jaundice. Methods Our research involved 96 patients diagnosed with malignant obstructive jaundice who were treated at our hospital from January 2020 to January 2024. They were divided into two groups of 48 participants each. One group received ERCP accompanied by stent insertion, and the other underwent ultrasound-guided PTCD. Perioperative indicators, treatment efficacy for low and high blockages, and pre- and post-operative levels of inflammatory markers and liver function markers were recorded and compared. Complications such as biliary infection, acute pancreatitis, bile leakage, and bleeding comparisons were also made between the groups. Methods The PTCD group exhibited prolonged surgery duration, increased intraoperative blood loss, longer time to ambulation, and lengthier hospital stay, with values of (79.8±7.6) min, (80.7±8.3) mL, (4.4±0.9) d, and (14.8±2.5) d, respectively, compared to the ERCP group [(70.2±7.3) min, (72.4±7.5) mL, (3.5±0.6) d, (10.2±2.1) d] (P<0.05). In the PTCD group, the effectiveness rate for treating high-level obstructions reached 95.2%, which was higher than that in the ERCP group (56.5%) (P<0.05). The overall treatment effectiveness rates were 79.2% for the PTCD group and 75.0% for the ERCP group (P>0.05). Postoperatively, the PTCD group showed higher levels of inflammatory markers and lower liver function indicators than the ERCP group. The incidence of complications was also lower in the PTCD group (8.3%) compared to the ERCP group (27.1%) (P<0.05). Conclusion Ultrasound-guided PTCD requires longer surgery and recovery times; however, it's beneficial in improving liver function and reducing complications in patients with malignant obstructive jaundice.

Key words: Ultrasound-guided percutaneous hepatic biliary drainage, Endoscopic biliary cholangiopancreatography, Obstructive jaundice from malignancy, Inflammatory markers

YANG Zheng-fang, QI Jia-gao, BAI Yu, HE Xiao-fei. Effectiveness of ultrasound-guided percutaneous transhepatic cholangiographic drainage for treating malignant obstructive jaundice and its influence on serum inflammatory markers[J]. Chinese Hepatolgy, 2025, 30(1): 117-121.

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