The predictive value of LSPS combined with GBWT for esophageal and gastric varices bleeding post endoscopic treatment

Abstract

Abstract: Objective To investigate the predictive value of Liver stiffness-spleen diameter-to-patelet ratio score (LSPS) combined with Gall bladder wall thickeness (GBWT) for esophageal and gastric varices bleeding post endoscopic treatment.Methods A total of 90 patients with hepatitis B-related cirrhosis and esophagogastric varices who received endoscopic variceal ligation, sclerosing agent injection, and tissue adhesive injection during hospitalization in the Second People's Hospital of Pingxiang from January 2020 to April 2024 were selected. According to whether bleeding occurred post treatment, they were divided into a bleeding group (22 cases) and a non-bleeding group (68 cases). The age, GBWT, platelet, alanine aminotransferase (ALT), hemoglobin, creatinine, LSPS, and CTP scores of the two groups were observed and compared. Through univariate analysis of the differences in the above indicators, variables with P<0.05 were included in binary logistic regression analysis to screen out independent risk factors of bleeding after endoscopic treatment. The receiver operating characteristic curve (ROC) was drawn, and the value of LSPS combined with GBWT in predicting esophagogastric varices bleeding after endoscopic treatment was evaluated according to the area under the ROC curve (AUC), and to determine the best cut-off point, sensitivity and specificity for predicting bleeding after endoscopic treatment of esophagogastric varices.Results Univariate analysis showed that there were significant differences in LSPS and GBWT between the two groups (P<0.01). Binary logistic regression analysis showed that LSPS and GBWT of the two groups were independently associated with bleeding after endoscopic treatment of esophageal and gastric varices (P<0.05). ROC analysis showed that the AUC of LSPS and GBWT in the two groups were 0.961 and 0.898, the best cut-off points were 11 and 2.5, the sensitivity were 0.818 and 0.864, and the specificity were 0.971 and 0.779, respectively.Conclusion LSPS and GBWT are independent risk factors for bleeding post endoscopic treatment of esophagogastric varices. LSPS combined with GBWT has a higher predictive value for bleeding after endoscopic treatment.

Key words: LSPS, GBWT, Predictive value, Esophageal and gastric varices, Cirrhosis after hepatitis B

LI Xia, ZENG Yuan, ZUO Na, LI Jia-ying, LU Yi. The predictive value of LSPS combined with GBWT for esophageal and gastric varices bleeding post endoscopic treatment[J]. Chinese Hepatolgy, 2025, 30(3): 316-318.

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