An analysis on the efficacy of CT parameters combined with FIB-4 and serum BNP, HIF-1α levels in predicting esophageal varices in patients with hepatitis B-related cirrhosis

Abstract

Abstract: Objective To analyze the efficacy of CT parameters combined with fibrosis-4 factor (FIB-4), serum brain natriuretic peptide (BNP), and hypoxia-inducible factor-1α (HIF-1α) levels in predicting esophageal varices (EV) in patients with hepatitis B-related cirrhosis.Methods This study included 106 patients with hepatitis B-related cirrhosis admitted to the Second People's Hospital of Mengcheng from June 2022 to June 2024. According to the presence of EV, patients were divided into an EV group (50 cases) and a non-EV group (56 cases). All patients underwent CT examination. Professional software was used to measure liver and spleen volumes, as well as to record the diameters of the main portal vein (MPV), splenic vein (SPV), and left gastric vein (LGV), FIB-4 was calculated, and serum BNP and HIF-1α levels were measured using the ELISA method. The efficacy of combined prediction for EV was evaluated using ROC curves.Results The spleen volume, MPV, LGV, FIB-4, serum BNP, and HIF-1α levels in the EV group were (592.33±83.30) cm³, (15.31±1.50) mm, (6.04±1.10) mm, (5.97±1.46), (183.23±21.38) pg/mL, and (22.14±5.03) pg/L, respectively, which were higher than those in the non-EV group [(457.70±77.46) cm³, (12.25±1.22) mm, (4.53±0.62) mm, (4.58±0.95), (161.36±16.75) pg/mL, (17.57±4.27) pg/L] (P<0.05). The combined sensitivity and specificity of spleen volume, MPV, LGV, FIB-4, BNP, and HIF-1α were 94.0% and 92.9%, respectively, with an AUC of 0.954.Conclusion The combination of CT parameters, FIB-4, serum BNP, and HIF-1α levels demonstrates good efficacy in predicting the occurrence of EV in patients with hepatitis B-related cirrhosis, making it worthy of clinical application. This combined predictive method not only enhances the accuracy of assessing the risk of esophageal varices but also provides effective intervention guidelines for clinicians, and contributes to improving patient outcomes.

Key words: Hepatitis B-related cirrhosis, Esophageal varices, CT parameters, Fibrosis-4 factor, Brain natriuretic peptide, Hypoxia-inducible factor-1α

SONG Ying-yu, WANG Yan, ZHANG Hong. An analysis on the efficacy of CT parameters combined with FIB-4 and serum BNP, HIF-1α levels in predicting esophageal varices in patients with hepatitis B-related cirrhosis[J]. Chinese Hepatolgy, 2025, 30(3): 319-321.

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