Quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) combined with computed tomography (CT) dynamic enhanced scanning in the diagnosis of benign and malignant liver space occupying lesions in children

Abstract

Abstract: Objective To analyze the quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) combined with dynamic enhanced computed tomography (CT) scanning in the diagnosis of benign and malignant liver space occupying lesions in children.Methods Clinical data of children with hepatic space occupying lesions who admitted to the Children's Hospital of Soochow University from July 2018 to May 2024 were retrospectively analyzed. They were divided into malignant group (46 cases) and benign group (153 cases) based on pathological examination results. The characteristics of CT scanning and quantitative parameters of DCE-MRI were compared between the two groups. Using the pathological examination as the gold standard, the consistency between CT dynamic enhanced scan and the gold standard in diagnosing benign and malignant liver space occupying lesions, ang the related factors of malignant liver space occupying lesions were analyzed. The diagnostic value of DCE-MRI quantitative parameters combined with CT dynamic enhancement in malignant liver space occupying lesions was analyzed.Results The maximum rise slope (MSI) (92.53±10.87), mean strengthening time (MET) (508.34±51.45) and positive enhancement score (PEI) (34.57±4.82) in the malignant group were lower than those in the benign group [265.14±29.76), 557.42±58.30) and 241], respectively. The initial area under enhancement curve (IAUC) in the malignant group (36.78±5.63) was higher than that in the benign group (23.41±4.29) (P<0.05). In the malignant group, the proportion of low enhancement in delayed stage (95.65%) and high enhancement in arterial stage (100.00%) were higher than those in benign group (0.00% and 11.11%, respectively) (P<0.05), and the proportion of equal enhancement in portal vein stage in the malignant group (67.39%) was lower than that in benign group (96.08%) (P<0.05). There was moderate consistency between CT dynamic enhanced scan and gold standard in the diagnosis of benign and malignant hepatic space occupying lesions (Kappa =0.735, P<0.05). MSI (OR=0.234, 95%CI: 0.103~0.532), PEI (OR=0.277, 95%CI: 0.122~0.629), IAUC (OR=3.823, 95%CI: 1.681-8.696) were associated with malignant liver space occupying lesions (P<0.05). The area under the curve (AUC) values of MSI, PEI, IAUC, CT dynamic enhanced scan and the combination of the four patients were 0.797, 0.803, 0.845, 0.819 and 0.913, respectively (P<0.05), and the AUC values of the combination with the above four indicators were higher (P<0.05).Conclusion MSI, PEI, IAUC and CT dynamic enhanced scanning have important value in the diagnosis of benign and malignant liver space occupying lesions in children, and the diagnostic value of their combination is higher.

Key words: Dynamic enhanced magnetic resonance imaging, CT dynamic enhanced scanning, Children, Hepatic space occupying lesion, Diagnostic value

WU Lin, CHEN Meng-meng, WANG Ai-ping. Quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) combined with computed tomography (CT) dynamic enhanced scanning in the diagnosis of benign and malignant liver space occupying lesions in children[J]. Chinese Hepatolgy, 2025, 30(3): 361-365.

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