Chinese Hepatolgy ›› 2025, Vol. 30 ›› Issue (5): 617-619.

• Frontier，Exploration and Controversy Liver Fibrosis & Cirrhosis • Previous Articles     Next Articles

A study on the influencing factors of liver stiffness in hepatitis B patients with liver fibrosis by STE/STQ

SUN Jing, QIAN Kui   

  1. 1. Ultrasound Department of Binhu Campus of Hefei First People's Hospital, Anhui 230092, China;
    2. Ultrasound Department of Hefei First People's Hospital, Anhui 230092, China
  • Received:2024-03-23 Online:2025-05-31 Published:2025-07-04

PDF (PC)

3

Abstract: Objective To analyze the influence factors of liver stiffness values (LSM) of hepatitis B patients with liver fibrosis determined by sonopalpation elastography (STE) and sonopalpation elastometry (STQ). Methods The clinical data of 80 patients with hepatitis B-related liver fibrosis treated in our hospital from January 2018 to December 2023 were retrospectively analyzed. The patients were divided into F1 (n=20), F2 (n=23), F3 (n=15), and F4 (n=22) groups according to the degree of liver fibrosis. Baseline data, laboratory indicators including alanine aminotransferase (ALT], aspartate aminotransferase (AST), prothrombin time, partially activated thrombin time, liver stiffness values of STE and STQ in all groups were compared. Correlation analysis was conducted to analyze the correlation between liver hardness values of STE and STQ, and the levels of ALT and AST. Results The levels of ALT, AST, LSMSTE and LSMSTQ in stage F4 group were (260.62±36.13)U/L, (120.97±23.65) U/L, (18.52±4.63) kPa, and (19.24±5.33) kPa, respectively, which were higher than those in stage F1, F2 and F3 patients. The levels of ALT, AST, LSMSTE, LSMSTQ in stage F3 group were 237.46±35.67) U/L, (105.43±21.33) U/L, (14.21±3.94) kPa, and (14.83±4.62) kPa, which were higher than those in stage F1 and F2 patients. Similarly, the levels of ALT, AST, LSMSTE, and LSMSTQ in stage F2 group were (207.32±33.58) U/L, (90.45±20.71) U/L, (11.63±3.58) kPa, and (12.45±3.94) kPa, respectively, which were higher than those of (185.33±30.64) U/L, (185.33±30.64) U/L, (76.54±19.26) U/L, (8.32±1.56) kPa, and (8.99±2.03) kPa in stage F1 patients (P<0.05); Correlation analysis showed that LSMSTE and LSMSTQ values were positively correlated with the levels of ALT and AST (r=0.658, 0.531, 0.613, 0.594, P<0.05). Conclusion The levels of ALT and AST are closely related to LSM, which may affect the results of STE/STQ in the examination of hepatitis B liver fibrosis. In the clinical evaluation of the degree of liver fibrosis, imaging and laboratory examination results should be comprehensively judged to further improve the diagnostic accuracy.

Key words: Acoustic palpation elastography, Sound palpation elasticity measurement, Hepatitis B, Liver fibrosis, Liver stifness