Clinical characteristics and therapeutic effect evaluation of patients with type 2 diabetes complicated with bacterial liver abscess

Abstract

Abstract: Objective To analyze the clinical features and therapeutic effects of type 2 diabetes mellitus (T2DM) complicated with bacterial liver abscess (BLA). Methods The clinical data of 77 patients with BLA between January 2022 and December 2024 were collected. Patients were divided into T2DM group and BLA group according to whether they were complicated with T2DM or not. The baseline data, clinical manifestations and signs, blood biochemical indexes and clinical outcomes of the two groups were compared. Results Among 77 cases of BLA, 31 cases were complicated with T2DM (T2DM group), and the other were simple BLA group (n=46). In T2DM group, the age, abscess course and respiratory infection were (54.3±9.7) years, (25.6±5.4) days and 11 cases (35.4%), which were significantly higher than those in BLA group [(47.8±9.0) years, (17.8±4.4) days and 4 cases (8.7%), P<0.05]. The clinical manifestations and signs of anemia, abdominal pain, weight loss and sepsis in T2DM group were significantly heavier than those in BLA group (P<0.05). The clinical manifestations or signs of anemia, abdominal pain, weight loss and sepsis in T2DM group were 6 cases (19.3%), 20 cases (64.5%), 28 cases (90.3%) and 21 cases (67.7%), which were significantly heavier than those in BLA group [1 case (2.2%), 7 cases (15.2%), 25 cases (54.3%) and 10 cases (21.7%), P<0.05]. After systemic anti-infection combined with necessary abscess puncture and drainage, supplemented by blood sugar control and reasonable diet, 6 cases were cured, 19 cases were improved, 5 cases were not cured and 1 case died in the group with T2DM, and the effective rate was 83.9%, while 9 cases were cured, 33 cases were improved, 4 cases were not cured and 0 cases died in the group with BLA alone, and the effective rate was 91.3%, with no statistical significance (χ²=1.862,P=0.172). Conclusion The clinical manifestations of BLA patients with T2DM are more complicated, and the condition is more serious. The inflammatory reaction is more intense, and the patients exhibits significant metabolic disorders. However, through systematic anti-infection treatment, abscess drainage and comprehensive intervention measures, most patients can still achieve a favorable therapeutic effect.

Key words: Bacterial liver abscess, Type 2 diabetes, Septicopyemia

XU Yan-lan, WANG Xiao-wei. Clinical characteristics and therapeutic effect evaluation of patients with type 2 diabetes complicated with bacterial liver abscess[J]. Chinese Hepatolgy, 2025, 30(5): 709-712.

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