The value of ultrasound-guided liver puncture biopsy in the etiologic analysis of unexplained liver disease

Abstract

Abstract: Objective To analyze the value of ultrasound-guided liver puncture biopsy in the etiological analysis of unexplained liver disease, and to provide a basis for improving the diagnostic rate of unexplained liver disease. Methods 100 cases of patients with unexplained liver disease admitted retrospectively from December 2019 to December 2023 were examined by ultrasound-guided hepatic aspiration biopsy, and clinical features combined with hepatic aspiration pathology were used as the “gold standard”. The results of ultrasound-guided hepatic aspiration biopsy examination and the diagnostic value of ultrasound-guided hepatic aspiration biopsy examination were compared. Results In 100 patients, clinical features combined with pathological examination by liver puncture led to a clear diagnosis of autoimmune liver disease, cholestatic liver disease, hyperbilirubinemia, steatohepatopathy, and alcoholic liver disease, which amounted to 94 cases, with a positive diagnostic rate of 94.00% (94/100). A total of 90 cases of autoimmune liver disease, cholestatic liver disease, hyperbilirubinemia, steatohepatopathy, and alcoholic liver disease were examined by ultrasound-guided hepatic perforation biopsy, with a positive diagnostic rate of 90.00% (90/100), a false-positive rate of 0.00%, and a Kappa value of 0.858, which showed a good concordance with the clinical features in combination with the hepatic perforation pathologic examination. The sensitivity, specificity, accuracy, and positive predictive value of ultrasound-guided liver puncture biopsy examination were 95.74%, 100.00%, 96.00%, and 100.00%, respectively, which were in high concordance with the clinical features combined with the pathologic examination of liver puncture, and had high diagnostic value, and the differences were not statistically significant (all P>0.05). Conclusion Ultrasound-guided hepatic puncture biopsy has demonstrated high diagnostic efficacy in the diagnosis and treatment of unknown causes of liver function abnormalities, and it can provide an accurate basis for clinical decision-making in a timely manner, thus effectively guiding the formulation and implementation of treatment programs.

Key words: Ultrasound, Hepatic aspiration biopsy, Liver disease, Autoimmune liver disease, Cholestatic liver disease

FAN Wen-tao, HE Fei, YAN Pan. The value of ultrasound-guided liver puncture biopsy in the etiologic analysis of unexplained liver disease[J]. Chinese Hepatolgy, 2025, 30(7): 1000-1004.

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