Abstract: Objective To analyze the influential factors of abnormal liver function in newborns with umbilical vein catheterization (UVC), and to provide theoretical basis for clinical prevention and treatment. Methods A total of 82 neonates receiving umbilical vein catheterization admitted to Jincheng People′s Hospital from February 2023 to November 2024 were selected. Gestational age, catheterization retention time, Apgar score < 7, PICC treatment history, catheterization depth and other data were collected. They were divided into two groups according to whether abnormal liver function occurred, and the basic data of neonates in the two groups were compared. To analyze the multiple factors of liver dysfunction caused by neonatal UVC. Results Apgar score < 7 68.75% (11/16), PICC treatment history 68.75% (11/16), catheterization depth (5.20±0.63) cm in the group with abnormal liver function were higher than those in the group without abnormal liver function 28.13% (18/66), 30.30% (20/66), (3.24±0.45) cm. The gestational age of (33.52±1.52) weeks was lower than that of the group without hepatic dysfunction (35.74±2.03) weeks, and the retention time of catheterization (17.13±2.85) d was longer than that of the group without hepatic dysfunction (14.24±2.34) d (P<0.05). Binary Logistic regression analysis showed that Apgar score < 7 [OR=5.867 (95%CI: 1.789~19.243)], catheterization depth [OR=7.546 (95%CI: 2.579~22.0767)], catheterization retention time [OR=1.574 (95%CI: 1.121~2.044)], PICC treatment history [OR=5.060 (95%CI: 1.554~16.472)] were risk factors for liver dysfunction of neonatal UVC, and gestational age [OR=0.512 (95%CI: 0.344~0.761)] was a protective factor for neonatal UVC liver dysfunction (P<0.05). Conclusion Catheterization retention time, PICC treatment history, Apgar score <7, gestational age and catheterization depth are the influential factors for the abnormal liver function of neonatal UVC.

Key words: Newborn, Umbilical vein catheterization, Abnormal liver function, Influencing factor