The application of quantitative ultrasound and GGT/PLT ratio in the evaluation of liver fibrosis in hepatitis B patients

Abstract

Abstract: Objective To analyze the application value of quantitative ultrasound and gamma glutamyltransferase (GGT)/platelet count (PLT) ratio in the evaluation of liver fibrosis in hepatitis B patients. Methods The clinical data of 108 patients with hepatitis B and liver fibrosis treated from January 2021 to January 2024 were retrospectively analyzed. Based on the degree of liver fibrosis, the patients were divided into S1 stage group (n=28), S2 stage group (n=30), S3 stage group (n=28), and S4 stage group (n=22). The quantitative ultrasound parameters and serum test results of each group were compared. Spearman rank correlation analysis was used to examine the correlation between quantitative ultrasound parameters and serum test results in hepatitis B patients with liver fibrosis. Results The quantitative ultrasound parameters of the patients in S4 stage group were higher than those in S1, S2, and S3 stage groups. The quantitative ultrasound parameters of the patients in S3 stage group were higher than those in S1 and S2 stage groups, and the quantitative ultrasound parameters of the patients in S2 stage group were higher than those in S1 stage group (F=95.866, 76.567, 36.158, 25.092, P<0.05). The GGT level and GGT/PLT ratio of the patients in S4 stage group were higher, whereas PLT level was lower than those in S1, S2, and S3 stage groups. The GGT level and GGT/PLT ratio of patients in S3 stage group were higher, whereas the PLT level was lower than those in S1 and S2 stage groups. The GGT level and GGT/PLT ratio of patients in S2 stage group was higher than that of patients in S1 stage group (F=265.225, 352.658, 222.817, P<0.05). The result of corelation analysis showed that ultrasound quantitative parameters in patients with hepatitis B and liver fibrosis were positively correlated with serum GGT level and GGT/PLT ratio, and negatively correlated with PLT level (P<0.05). Conclusion The quantitative evaluation of ultrasound, GGT/PLT ratio, and the degree of liver fibrosis in hepatitis B patients are closely related. In clinical diagnosis and treatment, the above indicators can be combined to evaluate the severity of the patients’ condition.

Key words: Ultrasonic quantitative evaluation, Gamma-glutamyltransferase, Platelet count, Hepatitis B, Hepatic fibrosis

WAN Pin-feng, ZHOU Shu-min, FANG Qun, LI Na. The application of quantitative ultrasound and GGT/PLT ratio in the evaluation of liver fibrosis in hepatitis B patients[J]. Chinese Hepatolgy, 2025, 30(8): 1076-1079.

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