The value of Rh system D, C, c, E, e antigen-compatible transfusion in individualized transfusion therapy for liver cirrhosis patients with upper gastrointestinal bleeding

Abstract

Abstract: Objective To explore the value of compatibility transfusion based on Rh system antigens (D, C, c, E, e) in individualized transfusion therapy for liver cirrhosis patients with upper gastrointestinal bleeding (UGIB). Methods A total of 100 liver cirrhosis patients with UGIB requiring transfusion at Leshan Hospital of Traditional Chinese Medicine from March 2022 to February 2025 were selected and randomly divided into two groups (50 cases each) using a random number table. All patients underwent blood type identification and antibody screening before transfusion. The control group received conventional ABO blood type and RhD antigen testing, while the observation group underwent Rh system D, C, c, E, e antigen testing. Transfusion efficacy, crossmatch success rate, irregular antibody screening results, pre- and post-transfusion blood parameters [red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT)], and transfusion adverse reactions were compared. Results The crossmatch success rate in the observation group (96.00%) was higher than that in the control group (80.00%) (P<0.05), while no significant difference was observed in transfusion efficacy (94.00% vs. 86.00%, P>0.05). The observation group had lower rates of irregular antibody positivity (4.00% vs. 20.00%) and Rh system antibody positivity (2.00% vs. 16.00%) (P<0.05), with no difference in mixed-field reaction frequency (2.00% vs. 10.00%, P>0.05). Post-transfusion RBC, Hb, and HCT levels increased in both groups, with higher values in the observation group (P<0.05). No significant difference was found in transfusion adverse reactions (4.00% vs. 12.00%, P>0.05). Conclusion The application of Rh system D, C, c, E, and e antigen compatibility transfusion in personalized transfusion therapy for patients with cirrhosis and UGIB demonstrates significant efficacy. It effectively improves blood matching success rates, reduces the positive rate of irregular antibodies, enhances routine blood parameters, and does not significantly increase the incidence of adverse transfusion reactions.

Key words: Liver cirrhosis, Upper gastrointestinal bleeding, Individualized transfusion, Rh blood group, Matched transfusion

WANG Jian, LEI Jian-dong, XU Shi-man, WU Lin-jun. The value of Rh system D, C, c, E, e antigen-compatible transfusion in individualized transfusion therapy for liver cirrhosis patients with upper gastrointestinal bleeding[J]. Chinese Hepatolgy, 2025, 30(8): 1089-1092.

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