Chinese Hepatolgy ›› 2025, Vol. 30 ›› Issue (9): 1204-1209.

• Liver Fibrosis&Cirrhosis • Previous Articles     Next Articles

A study on the recompensation of decompensated cirrhotic patients with genotype 3 hepatitis C viral infection based on propensity score matching analysis

XU Dan-qing1, ZHA Xing-kun2, SA Cai-fen1, MU Huan1, ZHANG Ying-yuan1, MOU Chun-yan1, LI Wei-kun1, LIU Li1   

  1. 1. Yunnan Clinical Center of Infectious Diseases, The Third People's Hospital of Kunming, Kunming 650020, China;
    2. The People's Hospital of Jinning District, Kunming 650600, China
  • Received:2024-10-10 Online:2025-09-30 Published:2025-11-05
  • Contact: LIU Li, Email: liuli197210@163.com

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Abstract: Objective Propensity score matching (PSM) analysis was used to investigate the factors affecting the occurrence of recompensation in decompensated cirrhotic patients with genotype (GT)-3 hepatitis C viral (HCV) infection, and to establish a prediction model. Methods A total of 184 patients admitted to Kunming Third People's Hospital from January 1, 2019 to December 31, 2022 who were diagnosed as decompensated cirrhosis related to GT-3a or 3b HCV infection were retrospectively collected. The relevant clinical data were collected. The re-hospitalized patients without portal hypertension-related complications within at least 1 year were grouped as the recompensated group (n=51), while the control group was not compensated (n=133). With a caliper value of 0.1, the recompensation group and control group with well-balanced PSM were obtained by 1∶1 matching. The factors that may affect the occurrence of recompensation were analyzed by univariate and Multivariant COX proportional risk regression model. Results One hundred and two cases were successfully matched, with 51 cases in the re-compensation group and 51 cases in the control group. Single factor Cox regression analysis showed that in the re-compensation group, there were 11 cases (21.6%) with a history of endoscopic treatment, 12 cases (23.5%) with Child-Pugh score A, 29 cases (56.9%) with Child-Pugh score B, 10 cases (19.6%) with Child-Pugh score C, 11 cases (21.6%) without ascites grading, 22 cases (43.1%) with small ascites, 18 cases (35.3%) with moderate to large ascites, Alb level of (31.83±5.73) g/L, PTA of (66.24±16.51)%, CD4+lymphocyte count of 541.36 (331.80, 722.98)/μL], which were significantly different when compared to those of 13 cases (9.8%), 9 cases (6.8%), 79 cases (56.4%), 45 cases (33.8%), 13 cases (9.8%), 33 cases (24.8%), 87 cases (65.4%), (28.55±5.77 g/L), PTA (54.78±16.00)%, and CD4+lymphocyte count [345.93 (235.38, 676.71)/μL] in the control group (HR=2.111, HR=2.485, HR=0.293, HR=1.060, HR=1.028, HR=1.002). The results of multivariate analysis showed that the history of endoscopic treatment (HR=2.718, 95%CI: 1.307~5.653, P=0.007), moderate to large ascites (HR=0.325, 95%CI: 0.117~0.903, P=0.031), PTA (HR=1.027, 95%CI: 1.004~1.051, P=0.023), and CD4+lymphocyte count (HR=1.002, 95%CI: 1.000~1.003, P=0.005) were the influencing factors of decompensation in cirrhotic patients with GT-3 HCV infection. Conclusion Recompensation is more likely to occur in decompensated cirrhotic patients with GT-3 HCV infection, with a history of endoscopic therapy, and less likely to occur in patients with a large amount of abdominal ascites. PTA and CD4+ lymphocyte count are closely related to the occurrence of recompensation. The established nomogram prediction model can effectively evaluate the probability of the occurrence of recompensation in GT-3 HCV infection related cirrhotic patients at decompensated stage.

Key words: Hepatitis C, Genotype 3, Decompensated liver cirrhosis, Recompensation, Influence factor, Prediction model