A clinical observation on the reversal of liver fibrosis and early cirrhosis in patients with chronic hepatitis B by entecavir antiviral therapy

Abstract

Abstract: Objective To observe the clinical application of entecavir antiviral therapy in reversing liver fibrosis and early cirrhosis in patients with chronic hepatitis B. Methods Eighty patients with chronic hepatitis B between February 2020 and February 2022 were selected in this study. They were divided into an observation group and a control group on the premise of meeting the drug use standard of the pharmacy department of the affiliated hospital of North Sichuan Medical College. Patients in the former group were given entecavir and those in the latter group were given pegylated interferon α-2b injection. The indexes of hepatitis B virus, liver function, liver fibrosis and clinical efficacy of the above groups were compared. Results In the observation group, the levels of deoxyribonucleic acid quantification of hepatitis B virus (HBV DNA), hepatitis B surface antigen (HBsAg), and hepatitis B virus e antigen (HBeAg) were (4.2 ± 0.1) IU/mL, (848.6 ± 115.6) U/mL, and (181.3 ± 70.0) U/mL respectively, all of which were significantly lower than those of [(4.6 ± 0.2) IU/mL, (939.1 ± 125.2) U/mL, and (222.2 ± 82.3) U/mL, P<0.05] in the control group. After 3 months of treatment, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (Alb), and total bilirubin (TBil) in the observation group were (48.2 ± 10.1) U/L, (45.6 ± 15.6) U/L, (43.2 ± 4.1) g/L, and (18.3 ± 3.0) μmol/L respectively, which were significantly lower than those of [(55.6 ± 10.2) U/L, (56.1 ± 15.2) U/L, (41.1 ± 3.2) g/L, and (20.2 ± 4.1) μmol/L, P<0.05] in the control group. After treatment, the levels of hyaluronic acid, type Ⅲ procollagen, laminin, and type Ⅳ collagen in the observation group were (84.22 ± 28.1), (38.2 ± 5.6), (36.2 ± 5.1), and (69.6 ± 6.6) respectively, all of which were significantly lower than those of [(115.1 ± 40.2), (41.1 ± 5.2), (40.1 ± 6.2), and (76.1 ± 8.2), P<0.05] in the control group. Conclusion Entecavir antiviral therapy can not only quickly restore liver function, but also further reduce the indicators of hepatitis B viral infection and liver fibrosis, with definite clinical effect.

Key words: Entecavir, Chronic hepatitis B, Liver fibrosis, Early cirrhosis, Reversal

LI Ling-jie, YANG Ming, WU Wei-ping, WU Ya-nan, HUANG Yong-peng. A clinical observation on the reversal of liver fibrosis and early cirrhosis in patients with chronic hepatitis B by entecavir antiviral therapy[J]. Chinese Hepatolgy, 2025, 30(9): 1215-1218.

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