Efficacy of ursodeoxycholic acid and S-adenosylmethionine combined with polyene phosphorylcholine in treating intrahepatic cholestasis of pregnancy and its impact on maternal and neonatal outcomes

Abstract

Abstract: Objective To observe the clinical efficacy of ursodeoxycholic acid and S-adenosylmethionine combined with polyene phosphorylcholine in the treatment of ICP patients, and to evaluate their effects on liver function, serum bile acid and maternal and infant outcomes. Methods A total of 80 ICP patients who received standardized prenatal care in the obstetrics outpatient clinics and delivered in the hospitals were selected from Nantong Sixth People's Hospital, Nantong Third People's Hospital, and Nantong Maternal and Child Health Hospital between May 2019 and May 2024. These patients were divided into a control group and a experimental group based on the administration of polyene phosphorylcholine. The differences in liver function, serum bile acids, and maternal-neonatal outcomes between the two groups were compared. Results Both groups exhibited marked reductions in pruritus severity scores, ALT levels, total bile acids (TBA), and total bilirubin (TBil) post-treatment compared to baseline values (all P<0.05), with the experimental group achieving significantly greater decreases in these parameters (P<0.05). Notably, the experimental group demonstrated a shorter duration of jaundice resolution compared to control group [(6.0±1.7) days vs. (8.1±2.3 days; P<0.05]. After treatment, compared with the control group, levels of cholic acid, glycocholic acid, and taurocholic acid in the experimental group were significantly lower (all P<0.05), while deoxycholic acid was significantly higher (P<0.05). Furthermore, the experimental group displayed significantly prolonged gestational age at delivery and higher neonatal birth weights (P<0.05), accompanied by reduced incidences of postpartum hemorrhage, cesarean section, meconium-stained amniotic fluid, and preterm birth when compared to the control group (all P<0.05). Conclusion Ursodeoxycholic acid and S-adenosylmethionine combined with polyene phosphorylcholine demonstrates significant efficacy in improving liver function, alleviating clinical symptoms, optimizing bile acid profiles, and enhancing maternal and neonatal outcomes in ICP patients, warranting further clinical promotion and application.

Key words: Intrahepatic cholestasis of pregnancy, S-Adenosylmethionine, Polyene phosphorylcholine

HAN Ya-qin, JIN Yan-qi, HUANG Li-li, CHENG Xiang-yan. Efficacy of ursodeoxycholic acid and S-adenosylmethionine combined with polyene phosphorylcholine in treating intrahepatic cholestasis of pregnancy and its impact on maternal and neonatal outcomes[J]. Chinese Hepatolgy, 2025, 30(9): 1276-1279.

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