Abstract: Objective Investigate the application value of point shear wave elastography (pSWE) combined with quantitative parameters of contrast-enhanced ultrasound (CEUS) in evaluating the curative effect of transjugular intrahepatic portosystemic shunt (TIPS) for liver cirrhotic patients complicated with portal hypertension (LC-PHT). Methods 108 patients with LC-PHT undergoing TIPS were enrolled in Jiangnan University Affiliated Wuxi Fifth Hospital between July 2022 and December 2024. Before treatment and at 3 months after treatment, pSWE and CEUS were performed to compare quantitative parameters [shear wave velocity (SWV) of liver and spleen, arrival time (AT), time to peak (TTP), peak intensity (PI), ascending branch slope (AS)] and Freiburg index of post-TIPS survival (FIPS). The relationship between pSWE, CEUS quantitative parameters and FIPS score was analyzed by Pearson correlation analysis. Results After TIPS, spleen SWV and FIPS score were (2.4±0.7) m/s and (-0.86±0.21) points, which were lower than those of (3.8±0.8) m/s, and (-0.56±0.14) points before treatment [P<0.05], TTP was shorter than that before treatment [(29.5±2.9) s vs. (35.6±3.8) s, P<0.05], PI and AS were (18.6±2.5) dB and (1.3±0.4) dB/s, which were higher than those of (13.4±2.0) dB and (1.0±0.3) dB/s before treatment [P<0.05]. In LC-PHT patients after TIPS, spleen SWV and TTP were positively correlated with FIPS score (r=0.47, P<0.05; r=0.51, P<0.05), while PI and AS were negatively correlated with it (r=-0.38, P<0.05; r=-0.41, P<0.05); However, liver SWV and AT was not correlated with FIPS score (r=0.08, P>0.05; r=0.14, P>0.05). Conclusion The clinical application value of pSWE combined with CEUS quantitative parameters is high in evaluating the curative effect of TIPS in LC-PHT patients.

Key words: Liver cirrhosis, Portal hypertension, Point shear wave elastography, Contrast-enhanced ultrasound, Quantitative parameter, Transjugular intrahepatic portosystemic shunt, Curative effect