Abstract: Objective To explore the application of ultrasound FibroTouch quantitative technology in screening for fatty liver disease and evaluating liver fibrosis in middle-aged and young patients undergoing physical examinations. Methods 296 young patients who underwent physical examinations in our hospital from January 2023 to September 2023 were selected as the research subjects, all patients underwent quantitative ultrasound FibroTouch examination. Detection of fatty liver disease and liver fibrosis were recorded by physical examination population. Gender and BMI of fatty liver diesease and liver fibrosis patients were recorded. Changes in hardness, elasticity, and fat attenuation were conpared among healthy individuals, fatty liver groups, and liver fibrosis groups. ROC curve analysis of hardness, elasticity, and fat attenuation were used to explore the predictive value for fatty liver and liver fibrosis. Results Among the 296 middle-aged and young patinets undergoing physical examination, 137 cases of fatty liver were detected, accounting for 46.28%. Among them, 39 cases of liver fibrosis were detected, accounting for 13.18%. The detection rate of fatty liver in males higher than females (P<0.05); the detection rate of liver fibrosis between different genders showed no significant difference (P>0.05). The detection rates of fatty liver with BMI of 18.5-23.9 kg/m², 24.0-27.9 kg/m², and ≥28.0 kg/m² higher BMI<18.5 kg/m² (P<0.05). The detection rate of fatty liver with a BMI of 24.0~27.9 kg/m² and ≥28.0 kg/m² higher BMI of 18.5~23.9 kg/m² (P<0.05). The detection rate of fatty liver with BMI≥28.0 kg/m² was higher than BMI 24.0~27.9 kg/m² (P<0.05); The detection rate of liver fibrosis among different BMI groupsshowed no significant difference (P>0.05). The fatty liver group and liver fibrosis group hardness, elasticity, and fat attenuation were higher than healthy population (P<0.05). The liver fibrosis group hardness, elasticity, and fat attenuation were higher compared to fatty liver group (P<0.05). The ROC curve analysis showed that the combination of hardness and elasticity values with fat attenuation had higher sensitivity and specificity in predicting fatty liver and liver fibrosis than hardness and elasticity values with fat attenuation (P<0.05). Conclusion Ultrasound FibroTouch quantitative technology has important predictive value in screening fatty liver disease and evaluating liver fibrosis in middle-aged and young physical examination patients, with good sensitivity and specificity, and is worth clinical reference.

Key words: Ultrasound FibroTouch quantification, Middle aged and young people, Fatty liver, Hepatic fibrosis, Body mass index