Abstract: Objective To analyze the influencing factors of cancer recurrence after indocyanine green guided laparoscopic partial hepatectomy. Methods The clinical data of 97 patients with indocyanine green-guided laparoscopic partial hepatectomy admitted to Suqian Hospital of Jiangsu Provincial People′s Hospital from January 2021 to December 2022 were retrospectively analyzed. All patients were followed up until October 2024, and were divided into recurrence group and non-recurrence group according to the recurrence of cancer. The cancer recurrence and relapse-free survival (RFS) of the patients were statistically analyzed. The influencing factors of cancer recurrence in patients with hepatocellular carcinoma (HCC) after indocyanine green guided laparoscopic partial hepatectomy, and the value of significant factors in predicting cancer recurrence in patients with HCC were further explored. Results Among 97 patients, 3 cases were lost ,so the total number of cases in this study was 94, including 36 patients with cancer recurrence and 58 patients without cancer recurrence. The mean RFS of 36 patients with recurrent cancer was 28.00 months (95%CI: 25.391 ~ 30.609). The serum AFP level (164.85±34.28) ng/mL, the rate of tumor number 2~3 (69.44%), low differentiation rate (55.56%) and microvascular infiltration rate (69.44%) in the relapsed group were higher than those in the non-relapsed group [(94.69±16.27) ng/mL, (29.31%), (27.59%), (46.55%)], the tumor diameter [(7.52±1.35) cm] was higher than that of the non-recurrence group [(5.31±1.06)cm] (P<0.05). Multivariate logistic regression analysis showed that high AFP levels [OR:1.152 (95%CI: 1.082 ~ 1.228)], large tumors [OR:5.046 (95%CI:2.672 ~ 9.527)], and numerous tumor [OR:5.481 (95%CI:2.213 ~ 13.576)], low differentiation degree [OR:3.281 (95%CI:1.369~7.863)], microvascular infiltration [OR:2.609 (95%CI:1.086~6.272)] were the risk factors for cancer recurrence in indocyanine green-guided laparoscopic partial hepatectomy (P<0.05). The ROC curve showed that the AUC value of the combination of these five factors to predict cancer recurrence was 0.973, which had high predictive value. Conclusion High AFP level, large and numerous tumors,low differentiation degree,and microvascular infiltration are all independent risk factors for cancer recurrence in patients undergoing indocyanine green-guided laparoscopic partial hepatectomy. The combination of the five factors can better predict cancer recurrence in patients and assist doctors to develop personalized postoperative management plans.

Key words: Indocyanine green, Laparoscopy, Partial hepatectomy, Cancer, Recurrence, Influencing factor